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$2.7 million awarded for metastatic colon cancer research
Date:10/11/2007

tive contributions to metastatic colon cancer research and treatment in the near future, said Margaret Foti, Ph.D., M.D. (h.c.), AACRs chief executive officer. We offer our congratulations to all four investigators and wish them continued success in accomplishing their very relevant and demanding research goals.

Kahn, in concert with his lab at USC, will apply his AACR-Littlefield grant to research and development of a new therapeutic agent that targets and weakens the β-catenin signaling pathway present in colon cancers. Currently, no treatment exists that is specifically aimed at reducing the functions of this pathway, and Kahn and his associates are dedicated to advancing this chemotherapeutic solution through clinical trials for metastatic colon cancer.

Expanding the knowledge and understanding of the connection between inflammation and metastasis of colon cancer will be the focus of Karin and his team of researchers at UCSD. The AACR-Littlefield grant will support Karins work to explore the effects of different types of inflammation on the spread of colon cancer and potentially inhibit the growth of metastases through the development of new anti-inflammatory therapeutic strategies. Karin is hopeful that his discoveries can lead to new ways of treating metastatic colon cancer, using both new and existing anticancer therapies.

Weiner and his team at Fox Chase Cancer Center will allocate AACR-Littlefield grant support for unprecedented research looking for functional approaches to identifying important drug response-modifying genes that can be therapeutically targeted to improve colorectal cancer treatment. Weiners research seeks an analytical and experimental basis for introducing new ways of treating colorectal cancers with existing agents, specifically EGFR pathway-targeted drugs. He expects that these findings can act as a vast resource for future research studies of this type.

Taketo of Kyoto University wi
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Contact: Jennifer Ryan
jennifer.ryan@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

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