Navigation Links
$13 million federal grant for research into vascular disease awarded to Weill Cornell
Date:1/16/2008

NEW YORK (Jan. 16, 2008) -- The National Heart, Lung, and Blood Institute (NHLBI) has awarded another $13 million grant to the Center of Vascular Biology at Weill Cornell Medical College in New York City for biomedical research into vascular disease -- specifically atherosclerosis and thrombosis, which are major risk factors for coronary artery disease, heart attack and stroke.

The Program Project Grant awarded to Drs. Katherine and David Hajjar represents a renewal of five ongoing projects that have already made major contributions -- elucidating the biology of cells of the artery wall, the blood cells with which they interact, and the principal cellular and genetic changes that take place in arteries that predispose them to the formation of plaque and blood clots.

The projects will continue investigations of the interactions between blood cells and vessels, testing the hypothesis that mediators -- substances including nitrogen oxides, reactive oxygen species and growth factors -- regulate blood-vessel cell activity and plaque formation, and that atherosclerosis acts like a blood clot, forming a "response to injury."

"Perhaps the greatest strength of Weill Cornell's Vascular Biology Program, which began 17 years ago, is its record of high-quality, collaborative scientific interactions and outstanding scientists who trained in this Center over the years. The complementary scientific strengths and discrete research talents of our investigators create effective research synergies and enhance the scope of our research goals," says Dr. David P. Hajjar, executive vice provost and senior executive vice dean of Weill Cornell Medical College, and dean and Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics at Weill Cornell Graduate School of Medical Sciences.

In 1995, Weill Cornell Medical College established a Center of Vascular Biology headed by Dr. David Hajjar. Institutional funds in excess of $5 million were designated for capital improvements, equipment and faculty development to support the program.

The five NHLBI Program Project Grant projects include the following:

  • Dr. Aaron J. Marcus (Medicine) leads a study of CD39 NTPDase1. The goal is to understand the critical role of the compound as the prime regulator of blood fluidity and thrombosis.

  • Dr. Katherine A. Hajjar (Cell Biology) leads a study of the stress response in vascular cells of Annexin 2, a receptor that mediates the breakdown of a blood clot, as it relates to atherosclerosis.

  • Dr. Barbara L. Hempstead (Medicine) leads a study on the role of Brain-Derived Neurotrophic Factor (BDNF) in the promotion of blood-vessel formation in heart-attack patients.

  • Dr. Steven S. Gross (Pharmacology) leads a study of mitochondria (a kind of cellular power plant) in the function and dysfunction of eNOS (endothelial nitric oxide synthase), an enzyme that relaxes the smooth muscle in blood vessels.

  • Dr. David P. Hajjar (Biochemistry & Pathology) leads a study on the activation of the enzyme cyclooxygenase (COX) in atherosclerosis by nitrogen oxide and the impact of this activation on atherogenesis (plaque formation).

By the end of this 20-year program in 2011, it is hoped that the array of molecular links that define atherogenesis and thrombosis will have been identified.


'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. First orchid fossil puts showy blooms at some 80 million years old
3. SyntheMed Completes $2.8 Million Equity Financing
4. Rutgers Genetics receives $7.8 million for autism research
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. UD leads $5.3-million research project on rice epigenetics
7. Rutgers high school outreach gets $3 million boost from NSF
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. UD leads $5.3-million research project on rice epigenetics
10. $22 million gift from Alfred Taubman launches new biomedical research institute
11. Nanobiosym awarded $2 million DTRA contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:5/21/2017)... ... May 20, 2017 , ... ... the lengthy trial and error process by finding the right antidepressant faster. ... strengthen the doctor-patient relationship through a personalized approach to treatment. , ...
(Date:5/18/2017)... ... 18, 2017 , ... Dr. Ralph Mobbs of the Neuro ... Wales Private Hospital. The procedure was performed on a 46-year-old male patient suffering ... prior to undergoing surgery. , The AxioMed viscoelastic disc is a next-generation disc ...
(Date:5/18/2017)... ... May 17, 2017 , ... NDA Partners Chairman Carl Peck, MD , ... Advantar Laboratories and President of Pharmaceutical Development Business Unit of Cardinal Health, has joined ... Cardinal Health, he was former Chief Operating Officer at Anaborex, Senior VP and General ...
(Date:5/18/2017)... (PRWEB) , ... May 17, 2017 , ... ... innovation and business process optimization firm for the life sciences and healthcare industries, ... the UDIs and Traceability for Medical Devices conference in Brussels, Belgium. , Crowley ...
Breaking Biology Technology: