Navigation Links
$12 million grant to probe root causes of heart failure
Date:11/2/2010

Researchers at the University of Illinois at Chicago have been awarded more than $12 million by the National Heart, Lung, and Blood Institute to investigate both the acquired and familial causes of heart failure -- with the aim of identifying markers for diagnosis and targets for cures.

The five years of new funding supports an ongoing program-project grant led by R. John Solaro, distinguished university professor and head of physiology and biophysics at UIC, that looks at one of the leading causes of death, disability and hospitalization in the western world. Heart failure occurs when the heart cannot pump effectively and is unable to meet the body's need for blood and oxygen. More than 5.5 million Americans suffer from heart failure, and 670,000 new cases are diagnosed each year, according to the American Heart Association.

"We're looking at the overarching problem of the maladaptive changes the heart undergoes that lead into a vicious cycle of failure," says Solaro.

His program, like other program-project grants, links the unique expertise of each investigator to those of the others. "The sum is greater than the individual parts," he said.

His collaborators are Brenda Russell, professor in physiology and biophysics; E. Douglas Lewandowski, professor in physiology and biophysics; and Pieter de Tombe, chair of physiology at Loyola University, Chicago. The projects expand the program that Solaro has led for 10 years.

Those 10 years have been "extraordinarily productive," resulting in dozens of papers in top-tier journals, said Russell, who is executive associate vice chancellor for research at UIC. A decisive factor for the NIH to extend a project grant is the productivity of the program, she said.

Projects led by Solaro and de Tombe investigate energy consumption by the molecular motors of the cardiac muscle, called sarcomeres, which generate the pressure to pump blood through the arteries. Pilot studies h
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. MegaMatcher Accelerator 3.0 for Rapid Biometric Identification Matches Up to 200 Million Irises or 100 Million Fingerprints Per Second
2. NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million
3. European R&D leaders assembled in Tel Aviv will invest $70 million in joint R&D initiatives
4. USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry
5. U of I receives $1.5 million to further sustainability in ornamental crop production
6. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
7. UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops
8. SAIC Awarded $23 Million Task Order by Defense Biometrics Identity Management Agency
9. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
10. LSUHSC awarded $12 million for cancer, infectious diseases research & research pipeline
11. 100-million-year-old mistake provides snapshot of evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2015)... JOSE, Calif. , May 8, 2015 Synaptics ... interface solutions, today announced that members of the executive management ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Waterfront Hotel in Boston, MA ... May 27, 2015 Time: 2:45pm ET Location: The New York ...
(Date:4/27/2015)... , April 27, 2015  For more than ... trade show has been the premier worldwide event for ... 2015 is a must-attend event for any local, national, ... into the emerging commercial markets and current applications of ... innovations of this projected $48 billion industry, and how ...
(Date:4/20/2015)... PASADENA, Calif. , April 20, 2015 ... San Gabriel Valley to implant a new miniaturized, wireless ... HF System is the first and only FDA-approved heart ... reduce hospital admissions when used by physicians to manage ... a sensor that is implanted in the pulmonary artery ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... School in Plymouth, UK, have carried out research that suggests ... children from health experts may not be enough to tackle ... been published in the most recent issue of the journal ... the EarlyBird study, which has followed the development of over ...
... Austrian and Swiss scientists conducted intensive studies of the ... mountains and valleys. Around the same time, the Swiss ... at locations above 5000 metres, studying and photographing the ... black and white photographs taken by these scientists are ...
... be the focus of the Society for Nutrition Education,s ... one small step in fighting world hunger. Food security ... immediate attention in order to combat the issues of ... Nutrition Education (SNE) encourages its members and the public ...
Cached Biology News:Recommendations for children's exercise lacking say experts 2'Himalaya -- Changing Landscapes' photo exhibition draws attention to the impacts of climate change 2'Himalaya -- Changing Landscapes' photo exhibition draws attention to the impacts of climate change 3World Food Day brings attention to food security around the globe 2
(Date:5/21/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) ... focused on the development of autologous cell therapies, ... International Society for Cellular Therapy (ISCT) on RepliCel,s ... in a Phase 1/2 clinical trial.  The presentation, ... 5:30 PM to 7:00 PM local time, will ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 This ... history, especially for lawns. US Patented Pearl’s Premium ... for lawns around the country that are coming out ... that addresses a number of major global concerns related ... the “non-grass” grass – the alternative to the standard, ...
(Date:5/20/2015)... Westport, CT (PRWEB) May 20, 2015 ... the 10th anniversary of its acquisition of Tiger-Sul. ... from Enersul (Calgary Alberta, Canada) in May 2005, H.J. ... line to build it into a comprehensive portfolio of ... the strength of H.J. Baker and the innovation of ...
(Date:5/20/2015)... , May 19, 2015 Research and ... the addition of the "Bone Morphogenetic Proteins ... Fusion, Trauma, Reconstructive and Oral - Maxillofacial) - ... Forecast 2014 - 2022" report to their ... market is studied based on the types of ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Global Bone Morphogenetic Proteins Market Industry Analysis 2014 - 2022 2
... student teams with high-tech diagnostic and surgical devices ... annual BMEidea awards at MD&M East Conference in ... June 10 Today three collegiate biomedical engineering ... The winners in the annual Biomedical Engineering Innovation, ...
... ... gene synthesis has long been misunderstood. DNA2.0 has cracked the code on ... technology. DNA2.0,s approach goes beyond codon arrangement, so the company is introducing ... patent has been proven to increase protein expression yields by up to ...
... Ongoing , , DALLAS, June 10 ... (OTC Bulletin Board: ACCP) , announced today ... Patent and Trademark Office that two US patents relating to ... the management of mucositis will issue in June as US Patent ...
Cached Biology Technology:NCIIA Honors Top Collegiate Biomedical Engineering Teams 2NCIIA Honors Top Collegiate Biomedical Engineering Teams 3DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches 2DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches 3Access Pharmaceuticals Announces Granting of Two US Patents for MuGard(TM) 2Access Pharmaceuticals Announces Granting of Two US Patents for MuGard(TM) 3
... ICE-LAP3 Mch3 Lyophilized solid. ... enzyme regulation and kinetics, cleavage of target substrates, and ... protein. One unit is defined as the ... Ac-DEVD-pNA Cat. No. 235400 per hour at 37 C ...
... Cytokeratin 5 / 6 Cytokeratin 5 ... basic type of cytokeratin expressed in basal, ... of stratified epithelia as well as transitional ... and mesothelioma. Cytokeratin 6 (56 kD) is ...
Bovine Coronary Artery Smooth Muscle Cells (BCASMC) (>500,000 cells)...
RECK (F-20)...
Biology Products: