Navigation Links
$12 million grant to probe root causes of heart failure
Date:11/2/2010

Researchers at the University of Illinois at Chicago have been awarded more than $12 million by the National Heart, Lung, and Blood Institute to investigate both the acquired and familial causes of heart failure -- with the aim of identifying markers for diagnosis and targets for cures.

The five years of new funding supports an ongoing program-project grant led by R. John Solaro, distinguished university professor and head of physiology and biophysics at UIC, that looks at one of the leading causes of death, disability and hospitalization in the western world. Heart failure occurs when the heart cannot pump effectively and is unable to meet the body's need for blood and oxygen. More than 5.5 million Americans suffer from heart failure, and 670,000 new cases are diagnosed each year, according to the American Heart Association.

"We're looking at the overarching problem of the maladaptive changes the heart undergoes that lead into a vicious cycle of failure," says Solaro.

His program, like other program-project grants, links the unique expertise of each investigator to those of the others. "The sum is greater than the individual parts," he said.

His collaborators are Brenda Russell, professor in physiology and biophysics; E. Douglas Lewandowski, professor in physiology and biophysics; and Pieter de Tombe, chair of physiology at Loyola University, Chicago. The projects expand the program that Solaro has led for 10 years.

Those 10 years have been "extraordinarily productive," resulting in dozens of papers in top-tier journals, said Russell, who is executive associate vice chancellor for research at UIC. A decisive factor for the NIH to extend a project grant is the productivity of the program, she said.

Projects led by Solaro and de Tombe investigate energy consumption by the molecular motors of the cardiac muscle, called sarcomeres, which generate the pressure to pump blood through the arteries. Pilot studies h
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. MegaMatcher Accelerator 3.0 for Rapid Biometric Identification Matches Up to 200 Million Irises or 100 Million Fingerprints Per Second
2. NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million
3. European R&D leaders assembled in Tel Aviv will invest $70 million in joint R&D initiatives
4. USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry
5. U of I receives $1.5 million to further sustainability in ornamental crop production
6. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
7. UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops
8. SAIC Awarded $23 Million Task Order by Defense Biometrics Identity Management Agency
9. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
10. LSUHSC awarded $12 million for cancer, infectious diseases research & research pipeline
11. 100-million-year-old mistake provides snapshot of evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... BATON ROUGE In a finding that has implications ... and planets elsewhere in the solar system, LSU Associate ... funded by the National Science Foundation, or NSF, this ... sediments of a lake that lies 800 meters (2600 ... sheet support "viable microbial ecosystems.", Given that more than ...
(Date:8/21/2014)... A study recently published in the journal Carcinogenesis ... a new role for the protein adenomatous polyposis coli ... of cancer-related deaths in the U.S. , Lead author ... Biosciences and co-leader of the Cancer Biology program at ... of her career trying to understand the various activities ...
(Date:8/21/2014)... State University have developed a novel and versatile modeling ... for creating new materials as well as for studying ... allows us to model much larger and more complex ... says Nan Li, lead author of a paper on ... Department of Materials Science and Engineering. "This is a ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... Cleveland Clinic and Riverain Medical today announced the ... to determine whether chest X-ray CAD (computer-aided detection) can ... program is designed to determine whether chest X-ray CAD ... an early stage when they are most treatable, leading ...
... arrived at the Red Planet. Almost four years later, ... its instruments send back a stream of images and ... its remarkable career by completing 5000 orbits of Mars. ... orbiter has revolutionised our knowledge of Mars, probing every ...
... human immunodeficiency virus (HIV-1) molecular machinery responsible for ... a study by investigators at the University of ... published November 23 in PLoS Computational Biology. ... of HIV-1 has so far foiled the best ...
Cached Biology News:Cleveland Clinic leading clinical program to improve early-stage lung cancer detection 2Mars Express -- 5000 orbits and counting 2Mars Express -- 5000 orbits and counting 3
(Date:8/21/2014)... August 21, 2014 2014 ... Industry” is a professional and in-depth research ... report provides basic Seaweed Fertilizer information, including ... chain structure as well as industry overview. ... including domestic market as well as global ...
(Date:8/21/2014)... New Rochelle, N.Y. (PRWEB) August 21, 2014 ... it is the first private college in the Mid-Hudson ... The College will now begin accepting applications from qualified ... , “We are very pleased to have been ... to support Governor Cuomo’s transformative initiative to stimulate economic ...
(Date:8/21/2014)... , Aug. 21, 2014  China Cord Blood Corporation (NYSE: ... plan to release financial results for the first quarter ... after market close in the US.  ... a.m. ET on Friday, August 29, 2014 to discuss ... the Company,s recent developments, followed by a question and ...
(Date:8/21/2014)... St. Louis, MO (PRWEB) August 21, 2014 ... premier, full service biopharmaceutical contract development and manufacturing ... selected by Progenics Pharmaceuticals, Inc., an oncology company ... targeting and treating cancer, to manufacture the anti-prostate ... Progenics’ PSMA ADC product candidate. Under the ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... strategies to create vaccines for avian flu through ... genetically-engineered virus-like particles (VLPs), ROCKVILLE, Md., Nov. 13 ... its strategy for treating avian flu,through genetically-engineered virus-like particles ... Clinic 6th Annual Medical Innovation,Summit., Novavax, Inc. believes ...
... Genaera,Corporation (Nasdaq: GENR ) will present at ... Center in Mannheim, Germany. Dr. Henry,Wolfe, Executive Vice ... overview on Tuesday, November 18, 2008 at 11:00 ... is developing trodusquemine (MSI-1436) for type 2,diabetes and ...
... Covanta Holding,Corporation (NYSE: CVA ), a world ... renewable energy facilities, today,announced that it has amended ... co-owners Ridgewood Maine, L.L.C. and Indeck Energy,Services, Inc., ... agreed to acquire these,two facilities for approximately $52 ...
Cached Biology Technology:Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009 2Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009 3Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009 4Genaera to Present at BIO-Europe 2008 2Covanta Announces Amended Terms for its Acquisition of Two Biomass Energy Facilities in Maine 2Covanta Announces Amended Terms for its Acquisition of Two Biomass Energy Facilities in Maine 3Covanta Announces Amended Terms for its Acquisition of Two Biomass Energy Facilities in Maine 4
... Use in any standard fixed-angle ... 16,000 g.,Spin- centrifuge tube filters ... within a centrifuge tube. They filter ... removal, HPLC sample preparation, removal of ...
... treated (or medium binding) polystyrene surface ... biomolecules through passive interactions,• Is suitable ... molecules, such as antibodies, that have ... with the surface,• Binding capacity of ...
... depth • Reusable, press-to-seal gasket and cover ... and disassembled for hybridizing and imaging thick ... with up to a 13 mm diameter. ... Minimize specimen handling, eliminate evaporation and leaking ...
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
Biology Products: