Navigation Links
$12 million grant to probe root causes of heart failure
Date:11/2/2010

Researchers at the University of Illinois at Chicago have been awarded more than $12 million by the National Heart, Lung, and Blood Institute to investigate both the acquired and familial causes of heart failure -- with the aim of identifying markers for diagnosis and targets for cures.

The five years of new funding supports an ongoing program-project grant led by R. John Solaro, distinguished university professor and head of physiology and biophysics at UIC, that looks at one of the leading causes of death, disability and hospitalization in the western world. Heart failure occurs when the heart cannot pump effectively and is unable to meet the body's need for blood and oxygen. More than 5.5 million Americans suffer from heart failure, and 670,000 new cases are diagnosed each year, according to the American Heart Association.

"We're looking at the overarching problem of the maladaptive changes the heart undergoes that lead into a vicious cycle of failure," says Solaro.

His program, like other program-project grants, links the unique expertise of each investigator to those of the others. "The sum is greater than the individual parts," he said.

His collaborators are Brenda Russell, professor in physiology and biophysics; E. Douglas Lewandowski, professor in physiology and biophysics; and Pieter de Tombe, chair of physiology at Loyola University, Chicago. The projects expand the program that Solaro has led for 10 years.

Those 10 years have been "extraordinarily productive," resulting in dozens of papers in top-tier journals, said Russell, who is executive associate vice chancellor for research at UIC. A decisive factor for the NIH to extend a project grant is the productivity of the program, she said.

Projects led by Solaro and de Tombe investigate energy consumption by the molecular motors of the cardiac muscle, called sarcomeres, which generate the pressure to pump blood through the arteries. Pilot studies h
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. MegaMatcher Accelerator 3.0 for Rapid Biometric Identification Matches Up to 200 Million Irises or 100 Million Fingerprints Per Second
2. NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million
3. European R&D leaders assembled in Tel Aviv will invest $70 million in joint R&D initiatives
4. USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry
5. U of I receives $1.5 million to further sustainability in ornamental crop production
6. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
7. UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops
8. SAIC Awarded $23 Million Task Order by Defense Biometrics Identity Management Agency
9. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
10. LSUHSC awarded $12 million for cancer, infectious diseases research & research pipeline
11. 100-million-year-old mistake provides snapshot of evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... digestion to disease resistance. Despite the fact that tropical ... planet, more is known about belly-button bacteria than bacteria ... working on Panama,s Barro Colorado Island discovered that small ... more than 400 different kinds of bacteria. The combined ... different kinds. , Bacteria in tropical forests may also ...
(Date:9/15/2014)... determined that a single group of microorganisms may be ... in the oceans, with implications for the global carbon ... an essential molecule required by most life on this ... group of microorganisms because it is so large and ... in maintaining the brain and nervous systems, as well ...
(Date:9/15/2014)... that reef biodiversity may not provide the level of ... In an international study published today, Professor David Bellwood ... Studies (Coral CoE) says we need to identify and ... In coral reefs, just as in any modern-day society, ... and functioning. , Professor Bellwood says, in many ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Researchers discover new producer of crucial vitamin 2Specialized species critical for reefs 2
... are often seen laughing and smiling, but this cheerful ... and seizures. , ,ew research in mice, ... alleviated. , Edwin Weeber, Ph.D., and colleagues reversed ... syndrome by preventing the inhibition of CaMKII, an enzyme ...
... sea levels in the centuries to come? Are we destroying ... oceans on the rise? Can aquaculture be environmentally sustainable? And ... coastal fisheries? , Most importantly, what can governments, industry and ... media are invited to join leading international researchers and government ...
... winner of the 2006 David Horrobin Prize for medical ... Assumption and No Two Alike, the article, "Parental selection: ... hairlessness and skin color" was judged to best embody ... in 2004, is awarded annually and named in honour ...
Cached Biology News:Angelman syndrome deficits rescued in mice 2Angelman syndrome deficits rescued in mice 3Are we killing the world's oceans? 2Why aren't humans furry? Stone-Age moms could be the answer 2
(Date:9/16/2014)...   Synthetic Biologics, Inc. (NYSE MKT: ... and drug programs targeting specific pathogens that cause ... the Company,s Investor Day in New ... syndrome (IBS) program, including its novel, oral product ... the keynote presentation, Mark Pimentel , MD, ...
(Date:9/16/2014)... LOUISVILLE, Ky. , Sept. 16, 2014 /PRNewswire/ ... laboratory technologies and products to hospitals, physician office ... announce that, effective October 1, 2014, it will ... in specified hospital market segments and as a ... in the 48 contiguous United States ...
(Date:9/16/2014)... In preparation for VARTECH 2014, 2FA, Inc., ... focused on authentication and SSO announced today that their ... generate a OTP through the presentation of an RFID ... RFID authentication, 2FA,s solutions have leveraged the existence of ... RFID authentication is broadly deployed in healthcare and other ...
(Date:9/16/2014)... 16, 2014 RENU 28, the world's first ... available for purchase in Australia and New Zealand in ... beginning September 16th. The tour will make stops in Brisbane ... on the 18th, Sydney on the 20th, and Melbourne on ... and New Zealand and to educate people about the new ...
Breaking Biology Technology:Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 2Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 3LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 32FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Wellness Company Hosts ASEA Australia Tour September 16-22 2
... , Key ... • receptor binding assay • LEADseeker • ... The α 2 -adrenergic receptors are G protein-coupled receptors ... as renal Na + re-absorption, insulin secretion, platelet aggregation, and neurotransmitter release ...
... Key words: NK2 • GPCR ... SPA Imaging Beads , ... a family of small neuropeptides. Members of this family include peptides, substance ... hemokinin-1 (1). Neurokinins are widely distributed throughout the central and peripheral nervous ...
... Key words: formalin-fixed ... degenerate oligonucleotideprimed PCR (DOP-PCR),• Cy3/Cy5-dCTP probe labeling • comparative,genomic ... array CGH , ... Human genomic DNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue ...
Cached Biology Technology:Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 2Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 3Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System 4Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 2Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 3Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System 4GenomiPhi amplification of FFPE tissue DNA for array CGH 2GenomiPhi amplification of FFPE tissue DNA for array CGH 3GenomiPhi amplification of FFPE tissue DNA for array CGH 4GenomiPhi amplification of FFPE tissue DNA for array CGH 5GenomiPhi amplification of FFPE tissue DNA for array CGH 6GenomiPhi amplification of FFPE tissue DNA for array CGH 7GenomiPhi amplification of FFPE tissue DNA for array CGH 8GenomiPhi amplification of FFPE tissue DNA for array CGH 9GenomiPhi amplification of FFPE tissue DNA for array CGH 10
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and Silencer Pre-designed siRNAs, ...
... Ambion's custom siRNA service provides the premium ... silencing research. Custom siRNAs can be readily ... base target sequence, or by providing the ... out Ambion's Silencer Validated and ...
Human SDNSF/MCFD2 Biotinylated Affinity Purified PAb...
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Biology Products: