Navigation Links
$12 million grant to probe root causes of heart failure

Researchers at the University of Illinois at Chicago have been awarded more than $12 million by the National Heart, Lung, and Blood Institute to investigate both the acquired and familial causes of heart failure -- with the aim of identifying markers for diagnosis and targets for cures.

The five years of new funding supports an ongoing program-project grant led by R. John Solaro, distinguished university professor and head of physiology and biophysics at UIC, that looks at one of the leading causes of death, disability and hospitalization in the western world. Heart failure occurs when the heart cannot pump effectively and is unable to meet the body's need for blood and oxygen. More than 5.5 million Americans suffer from heart failure, and 670,000 new cases are diagnosed each year, according to the American Heart Association.

"We're looking at the overarching problem of the maladaptive changes the heart undergoes that lead into a vicious cycle of failure," says Solaro.

His program, like other program-project grants, links the unique expertise of each investigator to those of the others. "The sum is greater than the individual parts," he said.

His collaborators are Brenda Russell, professor in physiology and biophysics; E. Douglas Lewandowski, professor in physiology and biophysics; and Pieter de Tombe, chair of physiology at Loyola University, Chicago. The projects expand the program that Solaro has led for 10 years.

Those 10 years have been "extraordinarily productive," resulting in dozens of papers in top-tier journals, said Russell, who is executive associate vice chancellor for research at UIC. A decisive factor for the NIH to extend a project grant is the productivity of the program, she said.

Projects led by Solaro and de Tombe investigate energy consumption by the molecular motors of the cardiac muscle, called sarcomeres, which generate the pressure to pump blood through the arteries. Pilot studies have identified possible therapies for common familial cardiac disorders for which there is presently no cure.

The project headed by Russell addresses the mechanisms for growth of the heart-muscle cells and the assembly of the sarcomeres during growth.

Lewandowski focuses on the metabolic pathways that supply energy to the molecular motors and on the coordination of energy supply and demand, which he says brings "a slightly new perspective" to the program. Cellular metabolism is a topic of intense interest now, he said, because scientists think "the interplay between protein function and expression in the heart, and metabolic processes in the cell, can either make or break the contractile function of the heart."


Contact: Jeanne Galatzer-Levy
University of Illinois at Chicago

Related biology news :

1. MegaMatcher Accelerator 3.0 for Rapid Biometric Identification Matches Up to 200 Million Irises or 100 Million Fingerprints Per Second
2. NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million
3. European R&D leaders assembled in Tel Aviv will invest $70 million in joint R&D initiatives
4. USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry
5. U of I receives $1.5 million to further sustainability in ornamental crop production
6. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
7. UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops
8. SAIC Awarded $23 Million Task Order by Defense Biometrics Identity Management Agency
9. Evidence is weak for tropical rainforest 65 million years ago in Africas low-latitudes
10. LSUHSC awarded $12 million for cancer, infectious diseases research & research pipeline
11. 100-million-year-old mistake provides snapshot of evolution
Post Your Comments:
(Date:11/19/2015)...  Based on its in-depth analysis of the biometric ... the 2015 Global Frost & Sullivan Award for Product ... this award to the company that has developed the ... the market it serves. The award recognizes the extent ... customer base demands, the overall impact it has in ...
(Date:11/17/2015)... PARIS , November 17, 2015 ... 17 au 19 novembre  2015.  --> Paris ... 2015.  --> DERMALOG, le leader de l,innovation ... à la fois passeports et empreintes sur la même ... pour les passeports et l,autre pour les empreintes digitales. ...
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be ... York on Wednesday, December 2 at 9:30 a.m. ET/6:30 ... CEO, will provide a corporate overview. th Annual ... 1:00 p.m. ET/10:00 a.m. PT . Jim Mazzola , ... corporate overview. --> th Annual Oppenheimer Healthcare Conference ...
(Date:11/24/2015)... Inc., a worldwide provider of clinical research services headquartered in ... has set a new quarterly earnings record in Q3 of 2015.  ... Q3 of 2014 to Q3 of 2015.   ... the establishment of an Asia-Pacific office to ... and Mexico , with the establishment ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
Breaking Biology Technology: