Navigation Links
$1.5 million NCI Grant to aid Huntsman Cancer Institute researcher study melanoma, sun damage link
Date:9/30/2013

SALT LAKE CITY -- The National Cancer Institute (NCI) has awarded Huntsman Cancer Institute investigator Matt VanBrocklin, Ph.D., more than $1.5 million over the next five years to continue studying the role of a gene called c-KIT in the origin and growth of melanoma, a devastating and sometimes deadly skin cancer. VanBrocklin is an assistant professor in the Department of Surgery at the University of Utah.

The majority of melanomas have mutations in a gene called BRAF. Mutations in c-KIT have already been identified as the most common cancer-causing event in certain melanoma subtypes that rarely harbor BRAF mutations, including a type of melanoma caused by chronic sun damage. Some clinical trials involving drugs that inhibit c-KIT's action showed good early responses, but tumors soon developed resistance to the drugs.

"Moving forward with melanoma treatments that focus on inhibiting c-KIT will require more research with animal models that faithfully mimic the human disease," said VanBrocklin. "We need to discover more details about how c-KIT works in melanoma tumors and what other genetic factors may be interacting with it as the cancer progresses and spreads to other parts of the body."

VanBrocklin has developed a novel melanoma mouse model that will allow deeper examination of c-KIT's role in melanoma's initiation and progression in living systems. The funding will allow VanBrocklin to continue studies using this mouse model to test whether active c-KIT can initiate melanoma. The research will also examine other genetic factors that could enhance c-KIT's action. The overall goal is to develop new, more effective treatments for patients whose melanoma tumors have c-KIT mutations.


'/>"/>

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. NOAA launches website holding millions of chemical analyses from Deepwater Horizon oil spill
2. CSHL is part of iPlant group awarded $50 million to create US biology cyberinfrastructure
3. UNLV, Sen. Reid Announce $20 Million NIH grant to support clinical health research
4. $50 million NSF grant to advance cyberinfrastructure for big data in life sciences
5. Current pledges put over 600 million people at risk of higher water scarcity
6. Wistar receives $1.5 million Department of Defense grant to ready prostate drug for clinical use
7. Field Museum to receive federal grant for unlocking 350 million years of biodiversity
8. UCLA scientists receive $2 million grant to improve quality of donor livers for transplant
9. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
10. NIMBioS wins $18 million renewal award from National Science Foundation
11. BrightFocus Foundation announces $7.2 million in grants for Alzheimers and vision disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... 2014)—It,s been millions of years since T. rex ... by Ohio University scientists is breathing life back into ... dinosaur snouts. The research has important implications for how ... to enhance the sense of smell and cool their ... Ohio University doctoral student Jason Bourke, lead author of ...
(Date:10/14/2014)... High doses of fish oil supplements, rich in omega-3 fatty ... irregular heartbeat in which the heart can beat as fast ... trial led by the Montreal Heart Institute were published in ... on October 7th. , For the trial, 337 patients with ... to 4 grams of fish oil a day or to ...
(Date:10/14/2014)... takes between 10 and 20 years to develop, ... of intervention if detected early, which may be ... Australian clinical researchers. , Dr Jeremy Humphris ... of Medical Research, analysed medical histories and tumour ... cancer patients, operated on between 1994 and 20122. ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... continues to shed its reputation as DNA's faithful sidekick. Now, ... have found that a class of small RNAs called microRNAs ... research had indicated. , "MicroRNAs are affecting the majority of ... level," says Andrew Grimson, a post-doctoral fellow in Bartel's lab. ...
... and insight to a looming pandemic , If health ... may bring with it one of the most sweeping, ... ever seen. , While that prospect would terrify the ... candidate at Lehigh University, who has been researching the ...
... story about the discovery , After reviewing ... an independent team of ornithologists has confirmed the existence ... data provided to them in the last few days ... at Yale, the University of Kansas, and Florida Gulf ...
Cached Biology News:MicroRNAs have shaped the evolution of the majority of mammalian genes 2MicroRNAs have shaped the evolution of the majority of mammalian genes 3Researcher says flu responders can learn from 1918 epidemic 2Researcher says flu responders can learn from 1918 epidemic 3Researcher says flu responders can learn from 1918 epidemic 4Independent researchers confirm the existence of ivory-billed woodpecker 2
(Date:10/18/2014)... October 18, 2014 The Biomass ... in the five years to 2014. The industry's expansion ... energy tax credits that encouraged the use of biomass ... portfolio standards (RPSs), which require local utilities to generate ... total energy portfolio. Increased campaigning for green technology also ...
(Date:10/18/2014)... The report " Cloud Analytics Market ... Speech; Machine; Video; Predictive Analytics: Global Advancements, Delivery ... Analysis (2013 - 2018) ", defines and segments ... segments with an in-depth analysis and forecasting of ... driving this market, various restraints, and opportunities impacting ...
(Date:10/17/2014)... have received a $451,781 Air Force Office of Scientific ... micro- and nano-scale level that will provide clues for ... Mechanical and Aerospace Engineering, said the new technology and ... X-rays of an aircraft,s wing., "We,ll be able to ... look at it on this scale," Huang said. "Certain ...
(Date:10/17/2014)... and HILDEN, Germany ...   , Translational research in cancer ... being presented at the American Society of Human ... 250,000-plus DNA samples linked to Ingenuity ®  Knowledge ... for genomic analysis  Ingenuity ®  Variant ...
Breaking Biology Technology:Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6
... May 24, 2010 Simbionix USA Corporation,the world,s leading provider of ... is launching,two new hands-on training systems- the Lap Nepherctomy simulation module and,the ... AUA annual meeting in San Francisco next week. , ... The Lap ...
... BEIJING , May 24 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... Weidong Yin ,Chairman, President & CEO, will present at the 2010 UBS Global ... London,England . Sinovac,s presentation is scheduled for Wednesday, June 2, 2010 ... , , ...
... ... ... plans to add to its natural color capabilities by investing $16 million at its Color ... facility dedicated wholly to natural colors production. The plant will be the largest and most ...
Cached Biology Technology:Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 2Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 3Sinovac to Present at 2010 UBS Global Specialty Pharmaceuticals Conference 2Sensient Technologies Corporation Announces Major Investment in Natural Colors 2
... using PULSin may be superior to transfection ... traditional transfection, with PULSin you can study ... time course of proteins in cells. Likewise, ... information than traditional RNA interference experiments. ...
... an automated instrument with a thin silicon ... using light or fluorescence microscopy. Biaxial strain ... fibroblast cells can be simulated by mechanical ... Y axis of our strain chamber. Strain ...
... The versatile ST-195 allows real-time observations ... conditions. This instrument has 64 different strain ... CO2 incubator. The thin silicon strain chamber ... inverted microscopes and fluorescence microscopy. ST-195 can ...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
Biology Products: