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$1.1 million NSF grant to fund research in advanced light microscopy at UCLA
Date:11/2/2007

pitalizes on the well-established advantages of fluorescence microscopy including sensitivity, molecular specificity, genetically encoded probes, live cells and ease of operation.

The STED concept relies on stimulated emission, coupled with smart optics, to sharpen the confocal excitation spot, resulting in more detailed, nanometer-resolved images. Bridging the gap between electron and diffraction-limited light microscopy, the STED microscope promises to be a powerful tool for unraveling the relationship between structure and function in cell biology.

The CNSI Advanced Light Microscopy/Spectroscopy shared facility currently provides training to more than 250 research students at the undergraduate, graduate and postdoctoral levels. The new microscope will be used in the education and training of students and researchers through a series of courses offered by the facility. The instrument will also be made available to a large network of researchers throughout Southern California and the United States.

Super-resolution STED microscopy holds great promise because it is expected to lead to significant new discoveries across the fields of biology, chemistry, materials sciences, engineering, medicine and physics.

"Super-resolution fluorescence microscopy will be decisive in solving long-lasting fundamental scientific questions which lie in this intermediate scale of tens of nanometers," said Bentolila, director of the Advanced Light Microscopy core lab at the CNSI.


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Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

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