Zinc finger: A protein structural motif common in DNA binding proteins. Four Cys residues are found for each "finger" and one finger can bind a molecule of zinc. A typical configuration is: CysXxxXxxCys--(intervening 12 or so aa's)--CysXxxXxxCys. Full article >>>
where CCCC is the DNA-binding domain that contains zinc fingers, and EEEE the ligand-binding domain. The latter is also responsible for dimerization of most nuclearic receptors prior to DNA binding. Full article >>>
Each of these functions depend upon a particular region of the protein (e.g., the zinc fingers for binding DNA). Mutations in any one region may upset the function of that region without necessarily interfering with other functions of the receptor. Full article >>>
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(Date:5/15/2008)...,, The human race was divided into two separ...s existence, says a Tel Aviv University mathematic...harsh conditions may have caused and maintained th...hool of Mathematical Sciences at Tel Aviv Universi...ambam Medical Center to analyze African DNA. Their...
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