Zinc finger

Zinc finger
A DNA binding protein structural motif. Present in many transcription factors (e.g., Sp1, Gal4). The "finger" is formed by 2-4 Cysteine residues and one zinc ion.
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Zinc finger (ZNF) genes represent one of the largest and most diverse family of genes found in the human genome.
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Zinc finger: A protein structural motif common in DNA binding proteins. Four Cys residues are found for each "finger" and one finger can bind a molecule of zinc. A typical configuration is: CysXxxXxxCys--(intervening 12 or so aa's)--CysXxxXxxCys.
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A Zinc Finger transcription factor that is the transcription factor of the Hedgehog signaling pathway.
Function/Pathway
"Ci is absolutely required for all examined aspects of Hh outputs" (Methot, 2001) ...
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where CCCC is the DNA-binding domain that contains zinc fingers, and EEEE the ligand-binding domain. The latter is also responsible for dimerization of most nuclearic receptors prior to DNA binding.
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Zinc fingers function as structural platforms for DNA binding.
Leucine zippers function in associating the transcription factors with each other.
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YAC yeast artificial chromosome A B C DE F G HI J K LM N O PQ R S TU V W XY Z zinc finger A specialized protein motif involved in DNA recognition by some DNA-binding proteins; ...
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Each of these functions depend upon a particular region of the protein (e.g., the zinc fingers for binding DNA). Mutations in any one region may upset the function of that region without necessarily interfering with other functions of the receptor.
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: Common sites on different proteins which facilitate their binding to DNA. Examples are leucine zipper and zinc finger proteins. Any such protein is called DNA-binding protein.
DNA
Polymerase ...
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