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Z-DNA


Z-DNA. A region of DNA that is "flipped" into a lefthanded helix, characterized by alternating purines and pyrimidines, and which may be the target of a DNA-binding protein.
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Z-DNA: Alternative left-handed form of the double helix which retains Watson-Crick type base pairing.
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(See b-DNA, cDNA, Complementary DNA or RNA, DNA polymorphism, DNA sequencing, Double-stranded complementary DNA, Duplex DNA, Z-DNA.) DNA diagnosis. The use of DNA polymorphisms to detect the presence of a disease gene. DNA fingerprint.
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Junction between B- and Z-DNA
Chromatin regions near the transcription start site frequently contain DNA sequence motifs favourable for forming Z-DNA. Likewise, formation of Z-DNA near the promoter region stimulates transcription.
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