Tumor suppressor

Tumor suppressor genes inhibit progression in tumor development. They usually inhibit abnormal cell growth or promote apoptosis. Examples include p53 and Rb.
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Tumor Suppressor Genes
Some genes suppress tumor formation.
Their protein product inhibits mitosis.
When mutated, the mutant allele behaves as a recessive; that is, as long as the cell contains one normal allele, tumor suppression continues.
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Dr. Lawrence Brody, of the National Human Genome Research Institute's Genetic and Molecular Biology Branch, defines tumor suppressor gene.
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terms:
BRCA1/BRCA2, cancer, gene, oncogene, p53 ...
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Tumor suppressor genes are genes with a wide variety of normal functions in the cell. I've always felt a little queasy about the idea of calling these tumor suppressor genes because it suggests that the gene evolved in order to suppress tumors.
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Tumor Suppressor
BRCA1 is believed to act as a tumor suppressor regulating cell growth and division. If suppressor genes are lost or damaged by mutation, uncontrolled cell growth can occur, resulting in cancer.
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Tumor suppressor gene
Apoptosis
Tumors (and related structures), Cancer, and Oncology
Benign - Premalignant - Carcinoma in situ - Malignant ...
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tumor suppressor genes Genes that normally keep cell division under control, preventing the cell from responding to internal and external commands to divide.
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tumor suppressor gene
A gene whose protein products inhibit cell division, thereby preventing uncontrolled cell growth (cancer).
tundra ...
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Tumor suppressor: A gene that inhibits progression towards neoplastic transformation. The best-known examples of tumor suppressors are the proteins p53 and Rb.
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Tumor suppressor: A gene that prevents tumor formation until deleted or mutated. The best-known examples of tumor suppressors are the proteins p53 and Rb.
Turnover: The balance between synthesis and degradation of a product.
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p53 A tumor suppressor protein found to be mutated in many types of cancer. palindrome A segment of duplex DNA in which the base sequences of the two strands is the same from each end of the strand.
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p53 protein. A tumor suppressor protein with critical functions in normal cells. A mutation in the gene that encodes it, p53, can result in loss of control over cell division and thus cancer.
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The process involves both oncogenes and tumor suppressor genes. Oncogenes promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a mutation.
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Breast cancer prognosis is associated with a tumor suppressor gene called p27.
Carcinogens
Carcinogens are chemicals that cause cancer by causing mutations.
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Tumor suppressor gene -- genes that normally function to restrain the growth of tumors; the best understood case is for hereditary retinoblastoma.
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