Tumor

Tumor suppressor genes inhibit progression in tumor development. They usually inhibit abnormal cell growth or promote apoptosis. Examples include p53 and Rb.
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Tumor Suppressor Genes
Some genes suppress tumor formation.
Their protein product inhibits mitosis.
When mutated, the mutant allele behaves as a recessive; that is, as long as the cell contains one normal allele, tumor suppression continues.
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Tumors of epithelial origin.
squamous epithelium: squamous cell papilloma , squamous cell carcinoma
transitional epithelium: transitional cell papilloma , transitional cell carcinoma
basal cell (only in skin): basal cell carcinoma ...
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A protective gene that normally limits the growth of tumors. When a tumor supressor is mutated, it may fail to keep a cancer from growing. BRCA1 and p53 are well-known tumor suppressor genes.
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A drug that is capable of either stopping or slowing the abnormal growth of tissue. Because the presence of tumors is one of the primary characteristics of cancer, anti-tumor drugs are often used to treat cancer.
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Tumor antigens are those antigens that are presented by the MHC I molecules on the surface of tumor cells. These antigens can sometimes be presented only by tumor cells and never by the normal ones.
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Tumor Biology
Cancer cells behave as independent cells, growing without control to form tumors. Tumors grow in a series of steps. The first step is hyperplasia, meaning that there are too many cells resulting from uncontrolled cell division.
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Tumor Suppressor
BRCA1 is believed to act as a tumor suppressor regulating cell growth and division. If suppressor genes are lost or damaged by mutation, uncontrolled cell growth can occur, resulting in cancer.
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Tumors need a blood supply for food and oxygen. Cancer cells release growth factors that cause nearby blood vessels to produce branches that grow into the cancerous tissue.
Immune System ...
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tumor
A mass that forms within otherwise normal tissue, caused by the uncontrolled growth of a transformed cell.
tumor suppressor gene ...
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tumor suppressor genes Genes that normally keep cell division under control, preventing the cell from responding to internal and external commands to divide.
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tumor necrosis factor. A cytokine, the most important source of which is macrophages, that is a major mediator of inflammation.
tumor A spherical mass of cells in which cell divisions occur at random and often in an uncontrolled fashion.
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Tumor DNA. See T-DNA.
Tumor-inducing plasmid. See Ti plasmid.
Tumor virus. A virus capable of transforming a cell to a malignant phenotype. (See Virus.) ...
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Tumor suppressor: A gene that inhibits progression towards neoplastic transformation. The best-known examples of tumor suppressors are the proteins p53 and Rb.
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Tumor suppressor: A gene that prevents tumor formation until deleted or mutated. The best-known examples of tumor suppressors are the proteins p53 and Rb.
Turnover: The balance between synthesis and degradation of a product.
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p53 A tumor suppressor protein found to be mutated in many types of cancer. palindrome A segment of duplex DNA in which the base sequences of the two strands is the same from each end of the strand.
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neoplasm (tumor) - a synonym for cancerous tissue
serotonin - increase vascular permeability and smooth muscle contraction. Originates from platelets ...
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swelling or tumor
Source: Noland, George B. 1983. General Biology, 11th Edition. St. Louis, MO. C. V. Mosby
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A malignant tumor derived from epithelial tissue, which forms the skin and outer cell layers of internal organs. Catalyst.
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Oncogenes -- genes involved in cell cycle control (growth factors, growth factor regulator genes, etc), a mutation can lead to tumor growth.
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Haas, Burnham and Mills 1997 used a multiobjective genetic algorithm to optimize the beam shape, orientation and intensity of X-ray emitters used in targeted radiotherapy to destroy cancerous tumors while sparing healthy tissue.
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Hematoma local swelling tumor or bruise filled with blood
(hemo = blood; -oma = tumor)
HemeGroup a porphyrin ring with iron in the center
(heme hemo = blood) ...
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Class I (from c-fos and c-myc mRNAs) AU rich elements destabilized neo reporter mRNA in a monocytic tumor cell line, but class II elements (from GM-CSF mRNA) did not (ref).
Destabilization
Monocyte tumor ...
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: A soil bacterium that causes a cancer-like plant disease (crown gall) in
dicotyledenous
plants (all agricultural crops except cereals). It contains the
Ti plasmid
. The
tumor ...
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