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Proteasome


Proteasomes are large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a...
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proteasome ( ′prōdēə′sōm ) ( biochemistry ) A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site
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The scientific resource for elucidating the Ubiquitin / Proteasome Pathway. ... Apoptosis meets proteasome, an invaluable therapeutic target of anticancer drugs. ...
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Ubiquitin and Proteasome
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Proteasome, signalosome, & TPPII ('Zomes') subunit data and nomenclature ' ... Subunit-Subunit Interactions of the 19S Regulatory Complex of the 26S Proteasome ...
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Proteasome Inhibitors: The multicatalytic proteasome is the ubiquitous ... The Pharmacokinetic and Pharmacodynamic Profiles of Proteasome Inhibitors ...
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Proteasome Inhibitors in Disease: The multicatalytic proteasome is the ... The Pharmacokinetic and Pharmacodynamic Profiles of Proteasome Inhibitors ...
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... Processing by Proteasomes. The Proteasome ... Structure of the Proteasome. The Core Particle (CP) ... The drug blocks the proteolytic action of the proteasome. ...
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Proteasome Complex ...
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Many inhibitors of proteasome protease activity are known, some of which are ... Several subunits of the proteasome are glycosylated with GlcNAc (N ...
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Ubiquitons and Zomes (Ubiquitin and Proteasome) ... Zomes (proteasome, COP9 signalosome and related complexes) ... Proteasome, COP9 signalosome, TPPII ...
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Proteasome inhibitor drug for treating cancer. ... Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome. ...
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The Proteasome-Glo™ Cell-Based Assays(a,b) are homogeneous, luminescent assays ... The 26S proteasome is a 2.5MDa multiprotein complex found in all eukaryotic cells. ...
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Designed to assay compounds for their ability to modulate proteasomal activity ... The ubiquitin/proteasome pathway is the main non-lysosomal route for ...
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... conditions by inhibiting the proteasome and thereby disrupting protein ... An orally-administered anti-cancer proteasome inhibitor would have the advantage ...
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Pfam is a large collection of protein families, represented by multiple sequence alignments and ... In eukaryotes the proteasome is composed of about 28 ...
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Author: Aldrin Gomes, Title: Proteasome, Date: 31 March 2009, Publisher: SciTopics ... Ubiquitin-proteasome-mediated protein degradation is essential in regulating ...
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The Ubiquitin-Proteasome System for Protein Degradation. Regulation of Both the ... Regulation of Proteasome Magnitude: Transcriptional Activation by Rpn4 ...
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