Probe

probe
a defined segment of DNA or RNA, usually carrying a radioactive label, used to identify a specific segment of DNA that carries the complementary base sequence
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition.
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The increase in the amount of probe molecules specific to a given target so that they can be easily detected. Examples include Q-beta and ligase chain reaction.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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Dr. Richard Morgan, of the National Human Genome Research Institute's Clinical Gene Therapy Branch, defines probe.
related
terms:
deoxyribonucleic acid (DNA), ribonucleic acid (RNA), antibody, gene ...
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Probe hybridization.
Joe Gray [University of California, San Francisco (UCSF) and LBL] reported on the LBL-UCSF Resource for Molecular Cytogenetics, ...
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Probe A labelled molecule which will recognise and bind to a specific target molecule, thus allowing detection of the target. DNA probes are used to locate and quantitate DNA (or RNA) of complementary sequence.
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Probes can be synthesized using a DNA synthesis machine. This requires a knowledge of at least a part of the sequence of the nucleotides in the gene to be probed so that a complimentary fragment can be created.
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Probe
A fragment of DNA labeled with radioactivity or chemiluminescence and used to hybridize to another DNA molecule to identify complementary base sequences.
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Probe: A fragment of DNA or RNA which is labeled in some way (often incorporating 32P or 35S), and which is used to hybridize with the nucleic acid in which you are interested.
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PROBE - Usually refers to a DNA or RNA molecule which has been labeled with 32P or with biotin, to facilitate its detection after it has specifically hybridized with a target DNA or RNA sequence.
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Probe. A single-stranded DNA that has been radioactively labeled and is used to identify complementary sequences in genes or DNA fragments of interest. (See Multilocus probe.) ...
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Probe: Single- stranded DNA or RNA fragment of specific base sequence, labeled either radioactively (often incorporating 32P or 35S) or immunologically, that are used to detect the complementary base sequence by hybridization.
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saprobe
[Gk. sapros, rotten, putrid + bios, life]
An organism that acts as a decomposer by absorbing nutrients from dead organic matter.
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saprobe An organism deriving its food from the dead body or nonliving products of another organism.
saprophagous Feeding on decaying matter; saprobic; saprozoic.
saprophyte A plant living on dead or decaying organic matter.
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If probes encounter a complementary sequence of nucleotides in a test sample of DNA, they bind to it by Watson-Crick base pairing and thus identify it.
Polymorphisms are inherited differences found among the individuals in a population.
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NANOPROBE SCANNING
A family of imaging techniques in which the interaction of a sharp, nanometre-sized tip with a specimen is measured as the tip is mechanically scanned over the specimen surface.
OPTICAL COHERENCE TOMOGRAPHY ...
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Atom probe
Atomic force microscope
Electron microscope
Field ion microscope
Field emission microscope
Phase contrast microscope , see Frits Zernike
Scanning tunneling microscope
Virtual microscope
X-ray microscope ...
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Scanning probe microscope
In scanning probe microscopy (SPM), a physical probe is used either in close contact to the sample or nearly touching it.
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Related Terms: Probe
Single-stranded DNA or RNA molecules of specific base sequence, labeled either radioactively, immunologically, or by other means, that are used to detect the complementary base sequence by hybridization.
Complementary DNA (cDNA) ...
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FISH using pairs of probes from distant segments of the same yeast chromosome reveals pairing of homologues in diploid interphase nuclei (ref). In a minority of nuclei, the pairing of homologous loci is particularly intimate.
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Most often used to describe the binding of a short primer or probe. Antibiotic. A class of natural and synthetic compounds that inhibit the growth of or kill other microorganisms.
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DNA probe -- any biochemical used to identify or isolate a gene, a gene product, or a protein.
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So it becomes really valuable to go in and actually look at tissues directly, at sections of tissues, and probe them with different probes that pick up different kinds of sugars. This, in a general sense, is glycobiology and it is very valuable.
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The European Space Agency and People's Republic of China both have plans to launch probes to explore the Moon in the near future, too. European spacecraft Smart 1 was launched September 27, 2003 and entered lunar orbit on November 15, 2004 .
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The probe hybridized in normal hemoglobin with two fragments 7000 or 7600 nucleotides long. Sickle-cell hemoglobin had hybridization with a 13,000 nucleotide single sequence.
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Synthesis provides unlimited diversity of the probe types (biotin, fluorescein, allyl, digoxygenin, 3H, radiolabelled I), glyco-particles, glyco-surfaces, multiarrays, immunogens etc. Several examples illustrate the most advanced applications.
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Southern blot A DNA hybridization procedure in which specific DNA fragments are detected in a mixture by means of a complementary, labeled nucleic acid probe.
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The closest linked marker (e.g., EST or a known gene) to the gene is used to probe a genomic library. A restriction fragment isolated from the end of the positive clones is used to reprobe the genomic library for overlapping clones.
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: One of the more modern methods in cytogenetics, which uses fluorescence-labelled chromosome-specific DNA, probes to detect translocations, inversions, deletions, amplifications and other structural or numerical chromosomal abnormalities.
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Sets of miniaturized chemical reaction areas that may also be used to test DNA fragments, antibodies, or proteins, by using a chip having immobilised target and hybridising them with probed sample.
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Probelesodon has developed a double joint in the jaw. The jaw could hinge off two points with the upper skull. The front hinge was probably the actual hinge while the rear hinge was an alignment guide.
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Southern blotting - technique in which DNA fragments, separated by electrophoresis, are immobilized on a paper sheet; specific molecules are then detected with a labeled nucleic acid probe ...
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