Pre-mRNA

The first (primary) transcript from a protein coding gene is often called a pre-mRNA and contains both introns and exons. Pre-mRNA requires splicing (removal) of introns to produce the final mRNA molecule containing only exons.
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pre-mRNA: An RNA molecule which is transcribed from chromosomal DNA in the nucleus of eukaryotic cells, and subsequently processed through splicing reactions to generate the mRNA which directs protein synthesis in the cytoplasm.
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When the pre-mRNA has been transcribed from the DNA, it includes several introns and exons. In nematodes, the mean is 4-5 exons and introns; in the fruit fly Drosophila there are more than 100 introns and exons in one transcribed pre-mRNA.
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RNA Processing: pre-mRNA → mRNA
All the primary transcripts produced in the nucleus must undergo processing steps to produce functional RNA molecules for export to the cytosol.
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Signals for nuclear pre-mRNA splicing were identified by consensus and genetic approaches.
Facts ...
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The name originally given to large RNA molecules found in the nucleus, which are now known to be unedited mRNA transcripts, or pre-mRNAs. (See RNA.) HGH. See Human growth hormone. hnRNA. See Heterogeneous nuclear RNA. Homologous chromosomes.
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RNA splicing is the normal process in which intron sequences are removed from the pre-mRNA, producing the mRNA, which corresponds to the exons.
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Simple illustration of pre-mRNA to mRNA splicing.
Introns sometimes allow for alternative splicing of a gene, so that several different proteins that share some sections in common can be produced from a single gene.
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These sites, key signals in3' flanking regions of a given group of genes, determinefeatures of 3'-end processing of pre-mRNAs.
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In alternative splicing, the same pre-mRNA molecule, which consists of introns and exons, is spliced in different ways to produce mature mRNAs of different lengths and different functionality.
altruistic behavior
(al-troo-is-tik) ...
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the nuclear RNA that still contains the introns (also referred to as pre-mRNA)
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row
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Poly(A) polymerase. Catalyzes the addition of adenine residues to the 3' end of pre-mRNAs to form the poly(A) tail. (See Polymerase.) ...
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Because of the complexity of the splicing process, one transcribed RNA may be spliced in alternate ways to produce not one but a variety of proteins (alternative splicing) from one pre-mRNA.
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