Nonsense Mutation

nonsense mutation
a mutation that changes a codon from one that specifies an amino acid into one that does not; there are three such nonsense codons
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
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Nonsense mutations
With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA).
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Nonsense mutation
Mutation that changes a codon or an amino acid to a termination or stop codon and leads to premature termination of translation.
Related Terms: Mutation ...
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nonsense mutations: code for a stop, which can truncate the protein.
missense mutations: code for a different amino acid.
silent mutations: code for the same amino acid.
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Nonsense mutation
A mutation which replaces a codon for an amino acid with a codon for chain termination (UAG, UAA, or UGA).
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nonsense mutation
A mutation that changes an amino acid codon to one of the three stop codons, resulting in a shorter and usually nonfunctional protein.
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Nonsense Mutation: A change in the sequence of a nucleic acid that causes a nonsense (stop or termination) codon to replace a codon representing an amino acid.
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Silent, Missense, and Nonsense Mutations
Three kinds of point mutations can occur. A mutation that results in an amino acid substitution is called a missense mutation.
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Mutations in boxes 1, 4, 5, and 6 are in exons and result in incomplete polypeptides (due to nonsense mutations). These mutations do not complement each other in trans.
Mutations in boxes 3, 10 and 7 are in introns and complement each other.
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Humans have 347 functional odor receptor genes; the other genes have nonsense mutations. This number was determined by analyzing the genome in the Human Genome Project; the number may vary among ethnic groups, and does vary among individuals.
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A mutation that affects the transcription or translation of part of the gene or operon downstream of the mutant site. For example, nonsense mutations, frameshift mutations, and insertion sequence(IS)-induced mutations.
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nonsense mutation A mutation that results in the premature termination of a polypeptide chain.
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Nonsense mutation -- a mutation in which a codon is changed to a stop codon, resulting in a truncated protein product.
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