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Native state


Stability of Native States
The most typical conformation of a protein in its cellular environment is generally referred to as the native state or native conformation.
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While it is clear that many unfolded proteins can attain their native state spontaneously in vitro, the efficiency of such folding is usually limited to conditions far removed from those encountered within cells.
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Recent advances suggest that whole microbial cells could be imaged by electron tomography to "molecular" resolution, sufficient to locate and identify large macromolecular complexes in their native state within their cellular contexts.
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They may only exist in their active, or native state, in a small range of pH values and under solution conditions with a minimum quantity of electrolytes, as many proteins will not remain in solution in distilled water.
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