Mispairing

Mispairing
The presence of a nucleotide in one nucleotide chain of a DNA molecule, which is not the complement of that at the corresponding position in the other chain.
Related Terms: Nucleotide ...
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Mispairing
Improper alignment of two nucleic acid strands.
Missense mutation
A mutation that changes a codon for one amino acid to a codon for a different amino acid, resulting in an amino acid substitution in the protein product.
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These high rates of mutation can be explained most frequently by slipped strand mispairing (slippage) during DNA replication on a single DNA double helix. Mutation may also occur during recombination during meiosis [4].
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A transition can be caused by nitrous acid, base mispairing, or mutagenic base analogs such as 5-bromo-2-deoxyuridine (BrdU). Less common is a transversion, which exchanges a purine for a pyrimidine or a pyrimidine for a purine (C/T ↔ A/G).
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Tautomerisms only represent damage when they cause mispairing during replication.
The inherent chemical instability of nucleotides is sufficient that, if uncorrected, the information in genomes would degenerate in a few generations.
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inversion sites, the largest share of which recognized the well-established pericentromeric inversions of chromosomes 1, 2, 9, and 18, as well as the paracentric inverted region of chromosome 7q11/q22. From this, we infer that meiotic mispairing ...
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