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Intron


intron
nucleotide sequences in nuclear RNA that are eliminated during the formation of mRNA; also called intervening sequences
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
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Intron RNA may have a large variety of interlocking regulatory functions not yet explored, including a role in gene silencing phenomena.
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Introns are transcribed as part of the normal gene primary transcript, but intron sequences are not found in the functional mRNA. Intron sequences are removed from the primary transcript by a splicing mechanism.
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Intron evolution
There are two competing theories as to the evolutionary origin of introns, which is usually studied in a highly conserved family of genes such as the actins.
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Dr. Jennifer Puck, of the National Human Genome Research Institute's Genetics and Molecular Biology Branch, defines intron.
illustrated:
View illustration ...
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Intron
The DNA base sequence interrupting the protein-coding sequences of a gene; intron sequences are transcribed into RNA but are cut out of the message before it is translated into protein.
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Intron DNA sequence that interrupts the protein-coding sequence of a gene; an intron is transcribed into RNA but is cut out of the message before it is translated into protein.
See also: exon ...
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intron In eukaryotes, bases of a gene transcribed but later excised from the mRNA prior to exporting from the nucleus and subsequent translation of the message into a polypeptide. PICTURE ...
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Intron
A sequence of a gene which is transcribed but which is excised by a splicing reaction before the mature mRNA is translated. Found in Eukarya, Archae, Bacteria, eukaryotic viruses, and phage.
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intron
A noncoding, intervening sequence within a eukaryotic gene.
invagination ...
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intron An intervening or noncoding segment of a gene; introns separate exons.
introvert A tubular, eversible extension of the head, bearing the mouth at its tip.
invagination An infolding of a layer of tissue to form a sac-like structure.
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intron - "intervening sequence," a stretch of nucleic acid sequence spliced out from the primary RNA transcript before the RNA is transported to the cytoplasm as a mature mRNA; ...
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INTRON - Intervening sequences in eukaryotic genes which do not encode protein but which are transcribed into RNA. Removed from pre-mRNA during nuclear splicing reactions.
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Introns are sequences of DNA that interrupt a gene, but do not code for anything. The coding portions of a gene are called exons.
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Intron: Introns are portions of genomic DNA which are transcribed (and thus present in the primary transcript) but which are later spliced out. They thus are not present in the mature mRNA.
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: Introns end with the dinucleotide
ApG
[3' splice site / acceptor] and start with the dinucleotide
GpT
[5' splice site / donor].
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The introns in most pre-mRNAs begin with a GU and end with an AG. Presumably these short sequences assist in guiding the spliceosome.
Visual Evidence ...
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Making Intron-Free DNA:
The DNA of eukaryotes is extremely long, containing many thousands of genes. It is often not possible to find specific genes in the DNA. Artificial genes can be made, however, using mRNA.
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Spliceosomal introns often reside in eukaryotic protein-coding genes. Within the intron, a 3' splice site, 5' splice site, and branch site are required for splicing.
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Intron. A noncoding DNA sequence within a gene that is initially transcribed into messenger RNA but is later snipped out. See Coding, DNA, Messenger RNA, Transcription. Invasiveness.
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Most known snRNAs have a role in the splicing reactions that remove introns from mRNA, tRNA, and rRNA molecules. SNDA Supplemental New Drug Application. somatic cells Body cells. All the cells except the germ-line cells.
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The situation is more complicated for eukaryotic genes, which often contain one or more noncoding regions (introns). To find ORFs in these genes, the introns are removed in a process called splicing (Fig. 3).
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Introns Sequences of non-coding bases found in eukaryotic genes. They may make up a large proportion of the total gene length. Introns are spliced out of the RNA transcript during its processing to mRNA.
kbp kilobase pairs.
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Moreover, the genes are often fragmented internally by non-coding sequences called introns, which can be many times longer than the genes themselves. Introns are removed on the heels of transcription by splicing.
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Mature transcript of RNA splicing which removes introns and joins exons in the primary transcript. mRNA usually has a 5' UTR, 3' UTR and polyA.
Related
3' UTR 5' UTR Mature transcript Primary transcript Splicing cis-splicing polyA trans-splicing ...
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RNA splicing - RNA-processing step in which all of the intron sequences are removed and exon sequences are kept therebv producing a much shorter RNA molecule.
second law of thermodynamics - the degree of disorder in the universe can only increase ...
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Introns -- a segment of DNA (between exons) that is transcribed into nuclear RNA, but are removed in the subsequent processing into mRNA.
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FRDA is caused by an expanded GAA repeat in intron 1 of the X25 gene encoding a protein called frataxin. Frataxin is widely expressed and is a mitochondrial protein, although its function is unknown.
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