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Homologous recombination


Homologous Recombination
Homologous (or general) recombination is at the heart of genetics.
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The exchange of pieces of DNA during the formation of eggs and sperm. Recombination allows the chromosomes to shuffle their genetic material, increasing the potential of genetic diversity. Homologous recombination is also known as crossing over.
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Homologous Recombination is the process by which two chromosomes, paired up during prophase 1 of meiosis, exchange some distal portion of their DNA.
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Homologous recombination
Substitution of a segment of DNA by another that is identical (homologous) or nearly so. Occurs naturally during meiotic recombination; also used in the laboratory for gene targeting to modify the sequence of a gene.
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Homologous recombination Swapping of DNA fragments between paired chromosomes.
Homology Similarity in DNA or protein sequences between individuals of the same species or among different species.
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Homologous recombination
The physical exchange of DNA between two homologous DNA molecules. Requires the RecA protein in enteric bacteria. Also called general recombination.
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Homologous Recombination. Here the broken ends are repaired using the information on the intact ...
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homologous recombination - process whereby stretch of DNA in a chromosome is replaced by a homologous (highly similar) DNA molecule for the purpose of altering the gene's function.
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Homologous Recombination: The exchange of sequence between two related but different DNA (or RNA) molecules, with the result that a new "chimeric" molecule is created.
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Homologous recombination. The exchange of DNA fragments between two DNA molecules or chromatids of paired chromosomes (during crossing over) at the site of identical nucleotide sequences. Homozygote.
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Gene disruption by homologous recombination
Knockout technology, as well as other genetic engineering approaches, depends on the ability to target genes for insertion into particular locations within the host chromosome.
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Method for the introduction of genetic modifications into specific genes by homologous recombination using Cre a site-specific, bacteriophage P1-derived recombinase. The Cre recombinase cuts at the loxP-tagged genes.
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Some of the electroporated stem cells will incorporate the new sequence into their chromosomes in place of the old gene; this is called homologous recombination . The reason for this process is that the new and the old sequence are very similar.
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