Some
organisms have evolved mechanisms of
gene amplification to provide
gene products needed in large quantities. These mechanisms include:
Elaboration of small "extrachromosomal" units that replicate to high copy number (r
DNA); ...
Full article >>>Dr. Lawrence Brody, of the National
Human Genome Research Institute's Genetic and
Molecular Biology Branch, defines
gene amplification.
related
terms:
cell,
deoxyribonucleic acid (
DNA),
gene,
oncogene ...
Full article >>>Gene amplificationMultiple copies of a single
gene within a
cell.
Gene conversion An genetic event that produces abnormal
segregations by non-reciprocal
recombination.
Full article >>>Gene amplification Repeated copying of a piece of
DNA; a
characteristic of
tumor cells.
See also:
gene,
oncogene ...
Full article >>>gene amplificationThe selective synthesis of
DNA, which results in multiple copies of a single
gene, thereby enhancing
expression.
gene cloning ...
Full article >>>Gene AmplificationIn
Drosophila (fruit flies), the chorion (egg
shell)
gene is copied many times in certain
cells of the
oviduct. These
cells make large quantities of the
protein needed to surround the
egg.
Full article >>>Gene amplification. The presence of multiple genes.
Amplification is one mechanism through which
proto-oncogenes are activated in malignant
cells.
Full article >>>(See
Dominant gene, Fusion
gene,
Gene amplification,
Gene expression,
Gene flow,
Gene pool,
Gene splicing,
Gene translocation,
Recessive gene, Regulatory
gene.)
Gene amplification. The presence of multiple genes.
Full article >>>Gene amplification -- any process by which specific
DNA sequences are replicated disproportionately greater than their representation in the parent
molecules; during development, some genes become amplified in specific
tissues.
Full article >>>Expression of cathepsin B is regulated at many different levels, from
gene amplification, use of alternative
promoters, increased
transcription and
alternative splicing, to increased stability and
translatability of
transcripts.
Full article >>>The probable answer:
gene amplification. Having multiple copies of genes permits a high level of
gene expression; that is, abundant
transcription and
translation to produce the
gene products.
Full article >>>Other genes undergo a process called
gene amplification where there may be two copies of the
gene present in normal
cells and 20 or 50 or a hundred copies of the
gene, often a growth promoting
gene, present in
cancer cells, ...
Full article >>>'"/>