Frameshift Mutation

frameshift mutation
a shift in the reading frame during translation, caused by the addition or deletion of bases in a DNA molecule
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
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Frameshift mutation
A mutation that alters the normal triplet reading frame so that codons downstream from the mutation are out of register and not read properly.
Related Terms: Mutation ...
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frameshift mutation
A mutation occurring when the number of nucleotides inserted or deleted is not a multiple of 3, thus resulting in improper grouping into codons.
free energy ...
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Frameshift Mutation: A mutation (deletion or insertion, never a simple substitution) of one or more nucleotides but never a multiple of 3 nucleotides, which shortens or lengthens a trinucleotide sequence representing a codon; ...
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A frameshift mutation is usually severe, producing a completely nonfunctional protein.
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These enzymes which break down the nylon oligomers appear to have arisen by frameshift mutation from some other gene which codes for a functionally unrelated enzyme. This adaptation has been experimentally duplicated.
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For example, a +1 frameshift mutation located a short distance downstream from a -1 frameshift mutation can restore the reading frame of a protein and thereby allow production of a functional product.
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Deamination base analogs (C→Uracil or A→HX); occurs 100 times each day in mammals
Transition
Transversion
Frameshift mutation (insertion or deletion on one strand), usually through a polymerase error when copying repeated sequences ...
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A chemical that can insert itself between the stacked bases at the centre of the DNA double helix, possibly causing a frameshift mutation.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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The 16 September 1999 issue of The New England Journal of Medicine reports the results of a year-long trial of recombinant human leptin in a 9-year-old girl who is homozygous for a frameshift mutation in her leptin genes. The findings: ...
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mutation also includes insertions or deletions of a single base pair (which have more of an adverse effect on the synthesized protein due to codons no longer being read in triplets, but in different orders- a mutation called a frameshift mutation).
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containing from 1 to 5 X chromosomes: 45, X; 46, XX; 47, XXX; 48, XXXX; and 49, XXXXX. An additional one, 49, XYYYY, is also available.
Patients with characterized BRCA1 gene mutations (including missense, nonsense, and frameshift mutations) and ...
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