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DNA gyrase


DNA gyrase, often referred to simply as gyrase, is an enzyme that supercoils DNA. Many antibiotics work by attacking bacterial DNA gyrase.
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Type II topoisomerases cut both strands of the DNA helix simultaneously in order to change the linking number of the molecule.
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Information about DNA gyrase in the free online English dictionary and ... identified by using flaB and DNA gyrase B subunit gene (gyrB) sequencing analysis. ...
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Thus, DNA gyrase appears to be an ideal target for antibacterial drugs. DNA gyrase cleaves a double strand, passes another duplex through it and reseals ...
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B. subtilis DNA gyrase is highly homologous to its well-studied Escherichia ... efficient in negative supercoiling as the E. coli DNA gyrase. ...
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DNA gyrase is a molecular machine that uses the energy of ATP hydrolysis to ... The equilibrium properties of DNA wrapped around gyrase or its subdomain have ...
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Here we show that it contains also a DNA gyrase. ... Reverse gyrase is a unique combination of a classical type I DNA topoisomerase ...
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DNA gyrase is distinct from all other topoisomerases in its ability to introduce ... These inhibitors stabilize gyrase–DNA covalent complexes, which are converted to ...
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Quinolone binding to the gyrase-DNA complex induces a conformational change that ... DNA gyrase is the intracellular target of the quinolone group of ...
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... have used limited proteolysis to identify conformational changes in DNA gyrase. ... DNA gyrase is a type II topoisomerase responsible for the manipulation of the ...
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Among these, DNA gyrase is exclusively present in prokaryotes and is essential ... The analysis of DNA gyrase from mycobacteria, which are gram-positive acid-fast ...
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Binding of the mAb did not affect either GyrA–GyrB or gyrase–DNA interactions. ... DNA gyrase purified from fluoroquinolone-resistant strains of M.tuberculosis and ...
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What is DNA gyrase? Meaning of DNA gyrase medical term. What does DNA gyrase mean? ... DNA gyrase. Also found in: Dictionary/thesaurus, Legal, Encyclopedia, ...
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Gyrase controls DNA supercoiling and re ... trapping of gyrase and topoisomerase IV on DNA probably ... gyrase removes negative supercoils from DNA (47, 189). Since ...
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DNA gyrase is a molecular machine that uses the energy of ATP ... through the activity of DNA gyrase, which works against mechanical ...
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The European Bioinformatics Institute ... II (called gyrase in bacteria) primarily ... DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel ...
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Gyrase also relaxes supercoiled DNA in an ATP-independent manner (14) ... In the domain of Archaea, TopoVI is often present and DNA gyrase is occasionally found (6) ...
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... gyrA and gyrB genes specifying the DNA gyrase subunits have been cloned into pET ... of the gyrase subunits reconstituted ATP-dependent DNA supercoiling with ...
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DNA gyrase is a target of quinolone antibacterial agents, but the molecular ... DNA gyrase consists of two proteins, GyrA and GyrB, which form an A2B2 complex ...
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