Classical genetics

Classical genetics works a little differently than any other field of science.
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Classical genetics consists of the techniques and methodologies of genetics that predate the advent of molecular biology. A key discovery of classical genetics in eukaryotes, was genetic linkage.
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In classical genetics, the stop codons were given names: UAG was amber, UGA was opal, and UAA was ocher. These names were originally the names of the specific genes in which mutation of each of these stop codons was first detected.
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Foundations of Classical Genetics from Electronic Scholarly Publishing
Franklin, Rosalind Anne Sayre Collection of Rosalind Franklin Materials from the American Society of Microbiology ...
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In practice, this method is used when classical genetics proves that a known piece of DNA is located on the chromosome close to a gene you would like to clone (such as a human disease gene).
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