Navigation Links
Tubulin


Tubulin is the protein which makes up microtubules. Microtubules are assembled from dimers of α- and β-tubulin. Each of these subunits has three domains. γ-tubulin is important in the nucleation and polar orientation of microtubule. Tubulin binds GTP and assembles onto the (+) ends of microtubules in the GTP-bound state. Once assembled into microtubules, it hydrolyzes GTP into GDP. The GDP-bound form of tubulin will disassemble from the tip of a microtubule, though it will not spontaneously fall out of the middle. This GTP cycle is essential for the dynamic instability of the microtubule.

Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be evolutionarily related to tubulin.

Delta and epsilon tubulin have been found to localize at centrioles and may play a role in forming the mitotic spindle during mitosis.

Pharmacology

Tubulins are targets for anticancer drugs like taxol. The anti-gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation.



'"/>


(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
(Date:11/21/2014)... 20, 2014 Strict laws against distracted driving ... the North American and European automotive sector towards gesture ... recognition systems that are intuitive and able to retrieve ... industry. New analysis from Frost & ... in Europe and ...
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... products are in the solid dosage form. Particulate ... include crystallization; drying, granulation, and coating; tablet compaction; ... other particulate processes are used for the large-scale ... dry powder inhalants for public consumption. As such, ...
... industries. They focus light to zap tumors and send digital ... But the physical length of an ordinary laser cannot be ... which limits its application in many industries. Now the Spaser, ... can be as small as needed to fuel nano-technologies of ...
... Newly released findings of a multinational survey ... (IOF) show clear disparities between patients, and doctors, ... 13-country survey of 844 postmenopausal patients over 55 ... between patient and doctor understanding of the emotional ...
Cached Biology News:Particulate Processes in the Pharmaceutical Industry III 2Particulate Processes in the Pharmaceutical Industry III 3Particulate Processes in the Pharmaceutical Industry III 4Particulate Processes in the Pharmaceutical Industry III 5Particulate Processes in the Pharmaceutical Industry III 6The 'Spaser' heats up laser technology 2Link between fracture prevention and treatment adherence not fully understood by patients 2
Other biology definitionOther Tags