Navigation Links
Sticky end/blunt end

In biology, sticky end and blunt end are the two possible configurations resulting from the breaking of double-stranded DNA. DNA exhibits a stabilizing interaction between complementary base pairs, providing specificity to the pairing of two strands of DNA. If two complementary strands of DNA are of equal length, then they will terminate in a blunt end, as in the following example:


However, if one strand extends beyond the complementary region, then the DNA is said to possess an overhang:


If another DNA fragment exists with a complementary overhang, then these two overhangs will tend to associate with each other and each strand is said to possess a sticky end:

5'-ApTpCpTpGpApCpT        pGpApTpGpCpGpTpApTpGpCpT-3'
3'-TpApGpApCpTpGpApCpTpApCpGp        CpApTpApCpGpA-5'


5'-ApTpCpTpGpApCpT pGpApTpGpCpGpTpApTpGpCpT-3'
3'-TpApGpApCpTpGpApCpTpApCpGp CpApTpApCpGpA-5'

The two fragments may then be covalently bonded by DNA ligase. Blunt ends may be ligated, but the reaction is significantly slower. These terms are most commonly used to describe the product of a restriction enzyme digestion of DNA.


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
Breaking Biology News(10 mins):
Other biology definition