Navigation Links
Protein biosynthesis



Protein biosynthesis is the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with transcription and ending with translation. Protein biosynthesis although very similar, differs between prokaryotes and eukaryotes.

Contents

Transcription

Main article: Transcription

Transcription only requires one strand of the DNA double helix. This is called the coding strand. The transcription starts with initiation. RNA polymerase, an enzyme, binds to a specific region on the DNA, marking the starting point, called the promoter. As the RNA polymerase binds on to the promoter, the DNA strands are beginning to unwind.

The second process is known as elongation. As the RNA polymerase travels through the strand that is opposite to the coding strand (the cell wants a copy of the coding strand, so it needs to copy that from the DNA that is the opposite of the coding strand), it matches corresponding mRNA nucleotides to the DNA.

As the polymerase reaches the termination stage, modifications are required for the newly transcribed mRNA to be able to travel to the other parts of the cell, including cytoplasm and endoplasmic reticulum. A 5’ cap is added to the mRNA to protect it from degradation. A poly-A tail is added on the 3’ end for protection and as a template for further process.

Translation

Main article: Translation

During translation, the message of mRNA is decoded to make proteins. Initiation and elongation occur when the ribosome recognizes the starting codon on the mRNA strand and binds to it. The ribosome has sites, which allow another enzyme, tRNA to bind to the mRNA. On tRNA, there is an anticodon that is used to match the codon on the mRNA. tRNA also has a single unit of amino acid attached to it.

As the ribosome travels down the mRNA one codon at a time, another tRNA is attached to the mRNA at one of the ribosome site. The first tRNA is released, but the amino acid that is attached to the first tRNA is now moved to the second tRNA, and binds to its amino acid. This translocation continues on, and a long chain of amino acid (protein), is formed.

When the entire unit reaches the end codon on the mRNA, it falls apart and a newly formed protein is released. This is the termination. It is important to know that during this process, many enzymes are used to either assist or facilitate the whole procedure.

Events following biosynthesis

The events following biosynthesis include protein folding and post-translational modification. During and after synthesis, polypeptide chains often fold to assume, so called, native secondary and tertiary structures. This is known as protein folding.

Many proteins undergo post-translational modification. This is may include the formation of disulfide bridges or attachment of any of a number of biochemical functional groups, such as acetate, phosphate, various lipids and carbohydrates. Enzymes may also remove one or more amino acids from the leading (amino) end of the polypeptide chain, leaving a protein consisting of two polypeptide chains connected by disulfide bonds.

External links


'"/>


(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America recently ... for carbon nanotube (CNT) macrostructures, including sheets, yarns and ... (UTD). Leveraging the vast industrial resources of ... Japan , Lintec of America is forming the ... TX , focusing on scaling up the manufacturing ...
(Date:2/5/2015)... , Jan. 26, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... corporate website ( http://www.nxt-id.com/ ) as part of its ... wallet. The Company launched its new consumer website for ... Pereira , CEO of NXT-ID said, "Our new corporate ...
(Date:2/5/2015)... , Jan. 28, 2015 Research and ... the addition of the "Global Biometrics Market ... Regions and Countries " report to their offering. ... Asia-Pacific is anticipated to ... 2015, owing to increasing government spending towards IT ...
Breaking Biology News(10 mins):Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3
... the prism of our senses, the human brain has ways ... is seen, for example, in the placebo effect, when simple ... seen to ease pain or have some other beneficial physiological ... the body to respond is largely a mystery of neuroscience. ...
... of Japanese scientists has discovered that cannabinoids can cause some ... the sites of infection and inflammation. These findings, which ... Biological Chemistry, could have potential use in the development of ... chemicals that include marijuana. These compounds bind to and ...
... are potentially limitless. In the long term it will ... to combat neurological disorders. What's more, it could allow ... as their CPU. , Those applications are potentially decades ... technology could enable very advanced and sophisticated drug screening ...
Cached Biology News:Great (taste) expectations: Study shows brain anticipates taste, shifts gears 2Researchers get neurons and silicon talking 2
Other biology definitionOther Tags