Navigation Links
Microsatellite


This article is about the DNA sequence. See miniaturized satellites for orbiting artificial satellites with a mass of less than 100Kg.

A microsatellite is a short, noncoding DNA sequence (a Tandemly Repetitive DNA sequence) that is repeated many times within the genome of an organism. Many repeats tend to be concentrated at the same locus.

In a microsatellite, the repeated sequence is very simple, consisting of two to four nucleotides, and can be repeated 10 to 100 times. Hence if one sequenced a microsatellite locus, one would expect to see a sequence of "TAGTAGTAGTAGTAGTAGTAG..."

The number of repeats at a particular locus is hypervariable (highly polymorphic) between individuals of the same species. It is for this reason that microsatellite sequences can be used for genetic fingerprinting and paternity testing. Most loci of the genome, even non-coding parts, would be too similar to allow individuals to be reliably distinguished.

The hypervariability arises because the repeated simple sequences cause a high frequency of loss or insertion of additional repeats by confusing the DNA replication machinery. Self-complementary sequences may aid this process.

In tumour cells, where controls on replication may be damaged, microsatellites may be gained or lost at an especially high frequency during each round of mitosis. Hence a tumour cell line might show a different genetic fingerprint from that of the host tissue.

See also: minisatellite, mobile element , transposon, short interspersed repetitive element , long interspersed repetitive element , junk DNA, selfish DNA


'"/>


(Date:7/11/2014)... The Chinese University of Hong Kong, BGI and other ... to salt tolerance, with implication for improving this important ... online in Nature Communications provides an effective ... , Soybean is an important crop for the world. ... less genetic diversities than their wild counterparts. Among the ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... Ume University, Sweden, have explored two different ways ... sequence leading to the formation of oxygen molecules ... in the scientific journal Nature Communications . ... day synthetic catalysts for water oxidation, which are ... the direct storage of solar energy in fuels ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... Lockheed Martin (NYSE: LMT ) has been ... of the Year" by Frost and Sullivan, recognizing the ... high levels of customer value. "Lockheed ... that play an important role our customer,s law enforcement ...
... Nitrogen is essential for plant growth. Despite the abundance ... must rely on a series of chemical reactions to ... forms. Plants have achieved this goal primarily by evolving ... nitrogen, plants, and the environment are the focus of ...
... Has a bone density scan placed you at risk ... bone-building medication? Not so fast! A University of Illinois study ... dietary calcium and vitamin D or taking calcium and vitamin ... be a last resort," said Karen Chapman-Novakofski, a U of ...
Cached Biology News:Lockheed Martin Named Biometrics "Company of the Year" by Frost and Sullivan 2Book looks at interrelationships among nitrogen, plants and the environment 2U of I study: Before you start bone-building meds, try dietary calcium and supplements 2U of I study: Before you start bone-building meds, try dietary calcium and supplements 3
Other biology definitionOther Tags