Navigation Links
Har Gobind Khorana


Har Gobind Khorana (born January 9, 1922) is a molecular biologist.

Khorana was born in Raipur (at that time India, now Pakistan). In 1945, he began studies at the University of Liverpool. After earning a Ph. D., he spend a postdoc year in Zrich (1948-49). He then returned to England and worked at Cambridge until 1952. He married Esther Elizabeth Sibler the same year. After that, he worked at universities in Vancouver and Wisconsin.

Khorana was awarded the 1968 Nobel Prize in Medicine (together with Robert W. Holley and Marshall W. Nirenberg) for describing the genetic code and how it operates in protein synthesis.

Khorana's synthetic RNA approach

RNAs with two repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This combined with the Nirenberg and Leder experiment showed that UCU codes for Ser and CUC for Leu.

RNAs with three repeating units (UACUACUA → UAC UAC UAC, or ACU ACU ACU, or CUA, CUA, CUA) produced three different strings of amino acids.

RNAs with four repeating units including UAG, UAA, or UGA, produced only dipiptides and tripeptides thus revealing that UAG, UAA and UGA are stop codons.

With this Dr.khorana and his team had established that the mother of all codes, the biological language common to all living organisms, is spelled out in three-letter words:each set of three nucleotides codes for a specific amino acid, in their Nobel lecture delivered on December 12,1968. Dr.Khorana was also the first to synthesize oligonucleotides , that is, strings of nucleotides. These custom designed pieces of artificial genes are widely used in biology labs for sequencing, cloning and engineering new plants and animals.Dr.khorana's invention of oligonucleotides has become indispensable tools in biotechnology. This invention of DrKhorana has become mechanized and commercialize that anyone now can order the synthetic genes just he needs to fax the genetic sequence.


'"/>


(Date:7/25/2014)... -- The routine use of a molecular testing ... of performing the correct initial surgery for patients ... the University of Pittsburgh Cancer Institute (UPCI), partner ... UPMC/UPCI Multidisciplinary Thyroid Center and other diagnostic testing ... correct initial surgery by 30 percent, according to ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... disturbance has different effects on different species of ... Universities of Bristol and Exeter which tested fish ... to a flying seagull predator model when exposed ... in European minnows. , Lead author Dr ... said: "Noise levels in many aquatic environments have ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4
... , During heavy rain, the lid of Nepenthes ... that seek shelter on its underside directly into the ... published today, Wednesday 13 June, in the journal ... insects as a source of nutrients, enabling them to ...
... unfathomable only a few years ago are reality today ... the acquisition of next-generation sequencing technology on the Texas ... of the service. "As we move into the ... in history," said Dr. Charles Johnson, director of the ...
... wide range of diseases and uncover fundamental processes that lead ... for biomedical science. A number of hurdles, both scientific and ... of using these special cells to treat heart disease, diabetes, ... June 13 in Nature , scientists at the Salk ...
Cached Biology News:Pitcher plant uses rain drops to capture prey 2Next-generation sequencing technology opens doors to discoveries 2'Magical state' of embryonic stem cells may help overcome hurdles to therapeutics 2'Magical state' of embryonic stem cells may help overcome hurdles to therapeutics 3
Other biology definitionOther Tags