Navigation Links
Cytotoxic T cell


A cytotoxic (or TC) T cell is a T cell (a type of white blood cell) which has on its surface antigen receptors that can bind to fragments of antigens displayed by the Class I MHC molecules of virus infected somatic cells and tumor cells.

Once activated by a MHC-antigen complex, TC cells release the protein perforin, which forms pores in the target cell's plasma membrane; this causes ions and water to flow into the target cell, making it expand and eventually lyse. TC also release granzyme, a serine protease, that can enter target cells via the perforin-formed pore and induce apoptosis (cell death).

Most TC cells have present on the cell surface the protein CD8 , which is attracted to portions of the Class I MHC molecule. This affinity keeps the TC cell and the target cell bound closely together during antigen-specific activation. TC cells with CD8 surface protein are called CD8+ T cells.


'"/>


See more about: Cytotoxic cell

TAG: Cytotoxic cell
(Date:11/23/2009)..., 2009 - The time of day matters to forest trees d...uced by a research team led by Professor Malcolm C...principal for research and colleagues in the depar...e campus. , Capitalizing on their previous wor...earch team examined how poplar trees use their 45,...
(Date:11/23/2009)...ew study provides "incontrovertible evidence" that... of Sumatra about 73,000 years ago deforested much...nter, researchers report. , The volcano ejected ...atmosphere, leaving a crater (now the world,s larg... 35 kilometers wide. Ash from the event has been f...
(Date:11/23/2009)...A new study by University of Alabama at Birmingham...) and co-existing medical conditions (co-morbidity...mong African-Americans compared to Caucasians who ...ine Nov. 23 in Cancer , a journal of the American...though BMI and co-morbidity are independent predic...
Breaking Biology News(10 mins):Time of day matters to thirsty trees, U of T researcher discovers 2Supervolcano eruption -- in Sumatra -- deforested India 73,000 years ago 2Racial disparity in colon cancer survival not easily explained, UAB researchers say 2PA Department of Health 3A National Delays in H1N1 Flu Vaccine Distribution Highlight Need for Continued Prevention Efforts 60327 1PA Department of Health 3A National Delays in H1N1 Flu Vaccine Distribution Highlight Need for Continued Prevention Efforts 60327 2Another Round 3A Wine Tasting Benefits Georgias Children Again 60325 1Another Round 3A Wine Tasting Benefits Georgias Children Again 60325 2Women Are at Greater Risk Than Men of Graft Loss After Undergoing Liver Transplantation for Hepatitis C related Liver Disease 60323 1Women Are at Greater Risk Than Men of Graft Loss After Undergoing Liver Transplantation for Hepatitis C related Liver Disease 60323 2Women Are at Greater Risk Than Men of Graft Loss After Undergoing Liver Transplantation for Hepatitis C related Liver Disease 60323 3
...omparing wild rodents with their laboratory counte...ter have found evidence that may help to explain w... stress hygiene have higher rates of allergy and a...d societies in which hygiene is harder to achieve ...thesis concerning the development of allergy and p...
...exploring a Colombian mountain range found survivi... extinct due to a killer fungus wiping out amphibi... discovery of what could be the last population of... indicates the species has survived the fungus, pr...limination from the epidemic caused by a pathogeni...
...at Karolinska Institutet have identified an import...e produced by each intestinal stem cell. The study...us scientific journal, Cell. "This might eventuall...ogical disorders and anaemia," says Professor Jona...are continually being replaced by new. If too many...
Other Biology News:Wild vs. lab rodent comparison supports hygiene hypothesis 2Wild vs. lab rodent comparison supports hygiene hypothesis 3Wild vs. lab rodent comparison supports hygiene hypothesis 4Colombian frog believed extinct found alive 2New stem-cell findings can help the body to cure itself 2
Other biology definitionOther TagseatereatereaterBankBankBankBankdisruptdisruptsayssayssayssayssaysholdsholdsholdsholdsmoldnownownownownowBushBushabilityabilityabilityabilityabilityability