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Collagen


Collagen is the main protein of connective tissue. It has great tensile strength, and is the main component of ligaments and tendons. It is responsible for skin elasticity, and its degradation leads to wrinkles that accompany aging. Collagen also fills out the cornea where it is present in crystalline form.

Collagen is the most abundant protein in mammals.

Contents

Features of collagen

Collagen has very interesting amino acid composition. It contains a lot of glycine and proline, as well as two amino acids that are not inserted directly by ribosomeshydroxyproline and hydroxylysine – the former composing a rather large percentage of the total amino acids. They are derivatised from proline and lysine in enzymatic processes of post translational modification, for which vitamin C is required. This is related to why vitamin C deficiencies can cause scurvy, a disease that leads to loss of teeth and easy bruising caused by a reduction in strength of connective tissue due to a lack of or defective collagen.

The white collagen that makes up the matrix of most connective tissue in mammals consists of inter-woven fibres of the protein collagen. The collagen fibres consist of globular units of the collagen sub-unit tropocollagen. Tropocollagen sub-units spontaneously arrange themselves under physiological conditions into staggered array structures stabilised by numerous hydrogen and covalent bonds. Tropocollagen sub-units are left-handed triple helices where each strand is, further, a right-handed helix itself. Thus, tropocollagen may be considered to be a coiled coil.

Another rare feature of collagen is its regular arrangement of amino acids in each of the alpha chains of the collagen sub-units. The sequence generally follows the pattern Gly-X-Y, where X is proline, and Y is proline or hydroxyproline. There are very few other proteins with such regularity. The inordinate number of Gly residues allows the otherwise sterically disallowed, tight coiling of each of the alpha chain subunits of tropocollagen, where there is a rise per turn of just 0.3 nm as opposed to the .36 nm of a regular Alpha helical coil. Hydroxylysine and hydroxyproline play important roles in the stabilisation of the tropocollagen globular structure as well as the final fibre shaped structure by forming covalent bonds. The resulting structure is called a collagen helix.

Types of collagen

Collagen occurs in many places throughout the body, and occurs in different forms known as types:

  • Type I collagen - This is the most abundant collagen of the human body. It is present in scar tissue , the end product when tissue heals by repair. It is found in tendons and the organic part of bone.
  • Type II collagen - Articular cartilage
  • Type III collagen - This is the collagen of granulation tissue , and is produced quickly by young fibroblasts before the tougher type I collagen is synthesised.
  • Type IV collagen - Basal lamina
  • Type V collagen - most interstitial tissue, assoc. with type I
  • Type VI collagen - most interstitial tissue, assoc. with type I
  • Type VII collagen - epithelia
  • Type VIII collagen - some endothelial cells
  • Type IX collagen - cartilage, assoc. with type II
  • Type X collagen - hypertrophic and mineralizing cartilage
  • Type XI collagen - cartilage
  • Type XII collagen - interacts with types I and III

See also

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