Navigation Links
Colchicine


Colchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (autumn crocus, meadow saffron) with the chemical formula C22H25NO6. Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present use is mainly in the treatment of gout.

Contents

History

The colchicine alkaloid was first isolated in 1820 by the two French chemists P.S. Pelletier and J. Caventon (Pelletier PS, Caventon J. Ann. Chim. Phys. 1820;14:69).

Colchicum extract was first described as a treatment for gout in De Materia Medica of Padanius Dioscorides.

It was later identified as a tricyclic alkaloid and its pain relieving and anti-inflammatory effects for gout were linked to it binding with the protein tubulin.

Pharmacology

Biological function

The molecular formula of colchicine is C22H25NO6. Name is N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide].

It inhibits the cytoskeleton by binding to tubulin, one of the main constituents of microtubules. Apart from inhibiting mitosis, a process heavily dependent on cytoskeletal changes, it also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect.

Colchicine as medicine

Colchicine is FDA-approved for the treatment of gout and also for familial Mediterranean fever, amyloidosis, and scleroderma. Side-effects include gastro-intestinal upset and neutropenia. Starting the drug early during an attack of gout can exacerbate the symptoms. High doses can also damage bone marrow and lead to anemia. It's not used in the treatment of cancer, as the dose required would lead to intolerable side-effects.

Toxicity

Poisoning resembles intoxication with arsenic: symptoms start 2 to 5 hours after the toxic dose has been ingested and include burning in the mouth and throat, fever, vomiting, diarrhea, abdominal pain and kidney failure. Death from respiratory failure can follow. There is no antidote.

Laboratory use

In laboratory setting colchicine is also used for inducing polyploidy in plant cells during cellular division.

External links


'"/>


(Date:8/27/2014)... Aug. 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... underwritten public offering of units of common stock and ... gross proceeds of $20 million, prior to deducting underwriting ... Company.  The shares and warrants are immediately separable and ... sold in the offering consists of 2,000 shares of ...
(Date:8/27/2014)... the mysteries of the human genome was unveiled today ... most detailed comparison yet of how the genomes of ... The research, appearing August 28 in in the journal ... the three species, genomes is "read out," and how ... The results add billions of entries to a publicly ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Law Enforcement Biometrics ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html About Biometrics Biometrics ... on the basis of their physical or behavioral ... both physiological traits such as fingerprints, face recognition, ...
Breaking Biology News(10 mins):WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5
... has identified a new genetic mutation responsible for osteogenesis imperfecta ... break, according to a study published today in the journal ... fractures in a lifetime or several hundred beginning before birth. ... from 20,000 to 50,000. While the study is an important ...
... combination of satellite data, computer models and weather balloon ... fires as much as doubled ground-level ozone thousands of ... July 2004. The study, which will appear online Sept. ... a rare glimpse at the precise air-quality effects from ...
... 1930s to estimate the abundance of fish has shown ... at reducing poaching of elephants, African buffaloes and black ... , "Wildlife within protected areas is under increasing threat ... argue that enforcement within protected areas is not sufficient ...
Cached Biology News:Researchers discover new gene responsible for brittle bone disease 2Researchers discover new gene responsible for brittle bone disease 3NASA study: Alaskan fires affected Houston air quality in 2004 2NASA study: Alaskan fires affected Houston air quality in 2004 3Serengeti patrols cut poaching of buffalo, elephants, rhinos 2
Other biology definitionOther Tags