Navigation Links
Cellular respiration


Cellular respiration is, in its broadest definition, the process in which the chemical bonds of energy-rich molecules such as glucose are converted into energy usable for life processes. Oxidation of organic material—in a bonfire, for example—is an exothermic reaction that releases a large amount of energy rather quickly. The overall equation for the oxidation of glucose is:

C6H12O6 + 6O2 → 6CO2 + 6H2O + energy

In cellular respiration, this oxidation process is broken down into two basic metabolic pathways: glycolysis, anaerobic respiration or aerobic respiration.

Contents

Glycolysis

Main article: Glycolysis

Glycolysis is a metabolic pathway that is found in all living organisms and does not require oxygen. The process converts one molecule of glucose into two molecules of pyruvate, and makes energy in the form of two molecules of ATP. Glycolysis takes place in the cytoplasm of the cell. The overall reaction can be expressed this way:

Glucose + 2 NAD+ + 2 ADP + 2 Pi → 2 NADH + 2 pyruvate + 2 ATP + 2 H2O + 4 H+

The individual steps of the conversion of glucose into pyruvate are (in brief):

  1. A glucose molecule from the hydrolysation of starch or glycogen is phosphorylated using one ATP molecule to give glucose-6-phosphate.
  2. The glucose-6-phosphate is converted to fructose-6-phosphate by isomerisation.
  3. Fructose-6-phosphate is again phosphorylated to give fructose-1,6-diphosphate with the use of another ATP molecule.
  4. Next, the fructose-1,6-diphosphate is then lysed into two molecules of 3-carbon sugar (dihydroxyacetone phosphate and glyceraldehyde-3-phosphate) which are interconvertible.
  5. The 3-carbon sugars are dehydrogenated and inorganic phosphate is added to them, forming two molecules of 1,3 diphosphoglycerate.
  6. The hydrogen is used to oxidise two molecules of NAD, a hydrogen carrier, to give NADH+H+. NADH+H+ later proceeds to the mitochondria for use in the electron transport chain.
  7. The two molecules of 1,3 diphosphoglycerate lose two phosphate groups to form two molecules of glycerate-3-phosphate (3-phosphoglycerate), converting two molecules of ADP to ATP.
  8. The two molecules of glycerate-3-phosphate again lose phosphate forming two molecules of pyruvate, with the production of another two ATP molecules (for a net gain of 2 ATP).

Breakdown of pyruvate

There are now two ways to break down the resulting pyruvate:

Aerobic respiration (Cellular Respiration)

Aerobic respiration requires oxygen. It is the preferred method of pyruvate breakdown. A molecule of pyruvate acid travels into a mitochondrion entering the Krebs cycle. In this process it is broken down producing energy in the form of ATP (which travels to the cell), NADH and FADH2 which travel to the electron transport chain. In this process, an electron is transferred from an energy-rich atom (such as a carbon atom in an organic molecule) to an oxygen atom, via an electron transport chain. Oxygen serves as the "terminal electron acceptor" in the electron transport chain. In the process, it yields 36 ATP molecules via the diffusion of hydrogen atoms through an ATP synthase, as well as carbon dioxide and water. This makes for a total gain of 38 ATP molecules during cellular respiration under optimal conditions; however, such conditions are generally not realized due to such losses as the cost of moving pyruvate into mitochondria. This takes place in the mitochondria in eukaryotic cells, and at the cell membrane in prokaryotic cells.

Anaerobic respiration (Fermentation)

"Anaerobic respiration" It does not require oxygen. True anaerobic respiration involves an electron acceptor other than oxygen. Bacteria are capable of using a wide variety of compounds as terminal electron acceptors in respiration: nitrogenous compounds (such as nitrates and nitrites), sulfur compounds (such as sulfates, sulfites, sulfur dioxide, and elemental sulfur), carbon dioxide, iron compounds, manganese compounds, cobalt compounds, and uranium compounds.

However, none of these alternative electron acceptors yields as much energy from respiration as does oxygen. In environments where oxygen is present, typically only aerobic respiration will occur.

Fermentation is a process in which pyruvate is partially broken down, but there is no Krebs cycle and no production of ATP by an electron transport chain. Fermentations of various kinds produce a number of different compounds. Textbook examples of fermentation products are ethanol (drinkable alcohol), lactic acid, and hydrogen. However, more exotic compounds can be produced by fermentation, such as butyric acid and acetone.

Although fermentation produces no ATP, it is useful to the cell because it regenerates nicotinamide adenine dinucleotide (NAD+), which is consumed by glycolysis.

Fermentation products contain chemical energy that cannot be further broken down by fermentation, making fermentation less efficient than respiration. Fermentation releases a total of two ATP molecules per molecule of glucose (compare to the approximately 38 of aerobic respiration).


See also

External links


'"/>


(Date:9/15/2014)... Sugar is a vital source of energy for both ... makes its way into the cell could lead to ... an increase in the amount of fruits and vegetables ... recently uncovered one of these "pathways" into the cell ... of a strand of spider silk. , To determine ...
(Date:9/15/2014)... of Australia,s leading coral reef ecologists fears that reef ... ecosystem survival that we once thought. , In an ... ARC Centre of Excellence for Coral Reef Studies (Coral ... most important species within reef ecosystems. , In coral ... vital jobs that keep the ecosystem safe and functioning. ...
(Date:9/15/2014)... Earth for the first 500 million years after it ... day, complete with oceans, continents and active crustal plates. ... called the Hadean, has gained substantial new support from ... more than 4 billion years ago with those formed ... possible geological analog for early Earth. , The study ...
Breaking Biology News(10 mins):X-rays unlock a protein's SWEET side 2X-rays unlock a protein's SWEET side 3Specialized species critical for reefs 2Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3
... dozens of shark species living in the coastal waters off ... the species, but a survey begun nearly 25 years ago ... populations and their role in marine ecosystems. NOAA scientists ... R.I., recently conducted their ninth coastal shark survey from Florida ...
... colorful leaves adorning the trees are a delight to the ... the United States and East Asia boast lustrous red foliage. ... autumnal hues around the world? A new theory provided by ... at the University of Haifa-Oranim and Prof. Jarmo Holopainen of ...
... team of researchers from Boston University, Harvard Medical School ... that changes a long held paradigm about how bacteria ... that causes human stomach ulcers uses a clever biochemical ... allowing it to move and survive and further colonize ...
Cached Biology News:Scientists conduct shark survey off US East Coast 2Scientists conduct shark survey off US East Coast 3Why are autumn leaves red in America and yellow in Europe? 2Why are autumn leaves red in America and yellow in Europe? 3Uncovering the secrets of ulcer-causing bacteria 2
Other biology definitionOther Tags