Navigation Links
Barr body


In those species in which sex is determined by the presence of the Y or W chromosome rather than the diploidy of the X or Z, a Barr body is the inactive X chromosome in a female cell, or the inactive Z in a male. This happens early in embryonic development at random in mammals, except in marsupials and in some extra-embryonic tissues of some placental mammals, in which the father's X chromosome is always deactivated.

The inactivation state of chromosomes is passed on to daughter cells during mitosis. Since random chromosomes are selected for inactivation early in embryonic development, this results in different regions of the adult body having different chromosomes inactivated. This can be significant if different alleles of a gene are present on the different chromosomes; in some regions of the body one allele will be active, and in other regions the other will. This is what results in the coloration pattern of female calico cats; pigmentation genes on the X chromosome are activated in different patches of skin based on which chromosome is condensed in those regions.

The Barr body chromosome is generally considered to be inert, but in fact a small number of genes remain active and expressed in some species. These genes are generally those which are present on the other sex chromosome (Y or W).

Mechanism

Mammalian X-chromosome inactivation is initiated from the X inactivation centre or Xic, usually found near the centromere. The centre contains twelve genes, seven of which code for proteins, five for untranslated RNAs, of which only two are known to play an active role in the X inactivation process, Xist and Tsix. The centre also appears to be important in chromosome counting: ensuring that random inactivation only takes place when two X-chromosomes are present. The provision of an extra artificial Xic in early embryogenisis can induce inactivation of the single X found in male cells.

The roles of Xist and Tsix appear to be antagonistic. The loss of Tsix expression on the future inactive X chromosome results in an increase in levels of Xist around the Xic. Meanwhile, on the future active X Tsix levels are maintained; thus the levels of Xist remain low. This shift allows Xist to begin coating the future inactive chromosome, spreading out from the Xic. In non-random inactivation this choice appears to be fixed and current evidence suggests that the maternally inherited gene may be imprinted .

It is thought that this constitutes the mechanism of choice, and allows downstream processes to establish the compact state of the Barr body. These changes include histone modifications, such as histone H3 methylation and histone H2A ubiquitylation , as well as direct modification of the DNA itself, via the methylation of CpG sites. These changes help inactivate gene expression on the inactive X-chromosome and to bring about its compaction to form the Barr body.

See also


'"/>


(Date:6/23/2015)... , June 22, 2015 ... the addition of the "Body-Worn Temperature Sensors ... Trends and Forecast 2014 - 2020" report ... strategic analysis of the global body-worn temperature sensors ... been segmented on the basis of types, care ...
(Date:6/18/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market announces that its Wocket® smart wallet ... on the Mark", scheduled to air on WABC Radio (am770) ... th . The broadcast air- time for ... 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira will ...
(Date:6/17/2015)... PALM BEACH GARDENS, Fla. , June 17, ... identity management solutions, today announced that its U.are.U ... by Togo,s Eateries, Inc., ... based fast casual sandwich chain, to increase security, ... (POS). The Crossmatch fingerprint readers enable instant, non-repudiable identity ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... of flavanols in cocoa has been developed by a ... of Mars, Incorporated, and recently published in the ... team,s expertise in flavanol chemistry and analytics, the method ... found in cocoa and chocolate products. Foods rich in ...
... Researchers at Johns Hopkins have identified a gene that ... developing neonatal intestinal obstruction, a potentially lethal complication of ... PLoS Genetics , along with the findings of ... Genetics , may lead to a better understanding of ...
... to protect itself against harsh weather or disease, that,s good ... plant. Bad because when a plant acts to defend itself, ... at Michigan State University, as part of an international collaboration, ... growth and defense, a finding that could help them strike ...
Cached Biology News:Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa 2Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction 2Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction 3Researchers find mechanism that gives plants 'balance' 2
Other biology definitionOther Tags