Megaloblastic anemia

Megaloblastic anemia
Definition:
Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12.
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Megaloblastic Anemia - View of Red Blood Cells
This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12.
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Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed.
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Lack of folic acid can also cause anemia, which is called megaloblastic anemia.
inherited conditions, such as sickle cell disease, thalassemia, and glucose-6-phosphate dehydrogenase deficiency ...
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Folic acid deficiency can result in a type of anemia called megaloblastic anemia. Mild folic acid deficiency usually does not cause any symptoms.
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A deficiency of folic acid after birth causes a kind of anemia, namely, megaloblastic anemia in which there is a paucity of red blood cells and those that are made are unusually large and immature (so-called blast cells).
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FOLIC ACID - A member of the B complex vitamin group; necessary for normal production of red blood cells; deficiency results in megaloblastic anemia.
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FOLINIC ACID: Also called citrovorum factor. A metabolically active form of folic acid that has been used in cancer therapy to protect normal cells against methotrexate-a cancer chemotherapy agent. Also used to treat megaloblastic anemias.
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Pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells (megaloblasts) that are forerunners of red blood cells. (Red blood cells, when mature, have no nucleus). It is thus a type of megaloblastic anemia.
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are ≥50% and the nonerythroid component is ≥20%, the diagnosis is erythroleukemia, whereas, if the nonerythroid component is <20%, the diagnosis is RAEB. The differential diagnosis for pure erythroid leukemia includes megaloblastic anemia ...
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