Intrinsic factor

Intrinsic factor
Definition:
Intrinsic factor is a protein produced by glands in the stomach lining. Itis necessary for the absorption of vitamin B-12 by the intestines.
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Intrinsic factor is a natural substance normally present in the stomach. It is essential to the digestion of vitamin B-12. Lack of intrinsic factor leads to pernicious anemia and vitamin B-12 deficiency.
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Absence of intrinsic factor, also called pernicious anemia - Intrinsic factor is a protein secreted by cells of the stomach lining. Intrinsic factor attaches to vitamin B12 and takes it to the intestines to be absorbed.
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Lack of intrinsic factor
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Aging of the stomach lining, with loss of special cells that secrete a protein called intrinsic factor (IF), which is essential to carry vitamin B12 into the body.
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Your body is not making intrinsic factor normally. For example, pernicious anemia is a fairly common condition in which your stomach does not have enough acid and also does not make intrinsic factor normally.
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A substance called intrinsic factor helps the intestines absorb vitamin B12. The inability to absorb vitamin B12 properly may be due to a lack of intrinsic factor or to a problem with the intestines.
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The stomach has to be able to produce what is known as "intrinsic factor," in order for vitamin B12 to be absorbed by the intestines.
Pernicious anemia rarely occurs under the age of 30, but it becomes more common with age.
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Pernicious anaemia - can develop when the stomach fails to produce intrinsic factor, which is needed to absorb vitamin B12. This leads to anaemia, causing headaches, tiredness and lethargy, and dizziness.
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Pernicious anemia: A blood disorder caused by inadequate vitamin B12 in the blood. Patients who have this disorder do not produce the substance in the stomach that allows the body to absorb vitamin B12. This substance is called intrinsic factor (IF).
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