Fanconi Anemia

Fanconi Anemia (FA) is a rare disease characterized by multiple physical abnormalities, bone marrow failure, and cancer susceptibility. FA is usually discovered between birth and age 10-15 years, however, there have been cases identified in adulthood.
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Fanconi anemia: A genetic disease that affects all of the bone marrow elements, is associated with a great diversity of malformations as well as pigmentary changes of the skin, and predisposes to malignancy.
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Fanconi pancytopenia: See Fanconi anemia.
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often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia. Also called Fanconi anemia.
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Having Fanconi anemia, a rare, genetic disorder, increases the likelihood of developing a myelodysplastic syndrome. Children born with other birth defects, including Down syndrome, may also be more susceptible to bone marrow disorders.
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The most common type of primary oral cancer in adults, squamous cell carcinoma (SCC), is extremely rare in children. Only occasional case reports are found in the literature.[48,49] Adolescents with an oral SCC should be screened for Fanconi anemia.
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