Transferrin receptor

Receptors for this protein, transferrin receptors (TfR), can appear on liver cell surfaces. Regulation of TfR is important to the regulation of iron uptake and metabolism.
The TfR mRNA is unstable when sufficient iron is present in the cell.
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1DE4 - Protein Data Bank entry for the Crystal Structure of Human Hemochromatosis Protein HFE Complexed with Transferrin Receptor
HFE Mutation Resources
Human Gene Mutation Database Entry for HFE ...
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The strong affinity of the transferrin receptor for transferrin (its ligand) ensures that the cell will get all the iron it needs even if transferrin represents only a small fraction of the protein molecules present in the ECF.
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juxtanuclear Smo showed no colocalization with the TGN marker TGN38 (Figure 3G) and instead colocalized with the transferrin receptor (Figure 2E).
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