Suppressor

Suppressor
A DNA sequence element to which transcriptional factors bind. Binding of transcriptional factors decreases gene transcription.
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Tumor Suppressor Genes
Some genes suppress tumor formation.
Their protein product inhibits mitosis.
When mutated, the mutant allele behaves as a recessive; that is, as long as the cell contains one normal allele, tumor suppression continues.
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A mutation that can suppress a variety of other mutations; typically a nonsense suppressor.
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Dr. Lawrence Brody, of the National Human Genome Research Institute's Genetic and Molecular Biology Branch, defines tumor suppressor gene.
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terms:
BRCA1/BRCA2, cancer, gene, oncogene, p53 ...
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Suppressor T cells do not activate or promote immune function following proliferation, but acts to decrease it instead.
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Suppressor mutation
A mutation that restores, partially or completely, the loss of function caused by another mutation.
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suppressor T cell (TS)
A type of T cell that causes B cells as well as other cells to ignore antigens.
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suppressor T cells T cells that slow down and stop the immune response of B cells and other T cells. Immune system cells that shut off the antibody production when an infection is under control.
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Suppressor gene A gene that can suppress the action of another gene.
Syndrome The group or recognizable pattern of symptoms or abnormalities that indicate a particular trait or disease.
Syngeneic Genetically identical members of the same species.
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Tumor suppressor genes are genes with a wide variety of normal functions in the cell. I've always felt a little queasy about the idea of calling these tumor suppressor genes because it suggests that the gene evolved in order to suppress tumors.
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Tumor-Suppressor Genes
Damaged or mutated DNA may result in uncontrolled cell growth.
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Tumor suppressor: A gene that inhibits progression towards neoplastic transformation. The best-known examples of tumor suppressors are the proteins p53 and Rb.
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Tumor suppressor: A gene that prevents tumor formation until deleted or mutated. The best-known examples of tumor suppressors are the proteins p53 and Rb.
Turnover: The balance between synthesis and degradation of a product.
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p53 A tumor suppressor protein found to be mutated in many types of cancer. palindrome A segment of duplex DNA in which the base sequences of the two strands is the same from each end of the strand.
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The process involves both oncogenes and tumor suppressor genes. Oncogenes promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a mutation.
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p53 protein. A tumor suppressor protein with critical functions in normal cells. A mutation in the gene that encodes it, p53, can result in loss of control over cell division and thus cancer.
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In class I mutants, no mutation was evident in trpA -- evidently a suppressor mutation occured (a mutation in another gene, usually tRNA, to compensate for another mutation.) In the trpB region, all the classes had the correct mutation.
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: One of the first phenomena in the formation of malignancies. It is due to defects in DNA repair and cell cycle controls. This can happen by gain-of-function mutations in proto-oncogenes or loss-of-function mutations in
tumor
suppressor genes.
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Tumor suppressor gene -- genes that normally function to restrain the growth of tumors; the best understood case is for hereditary retinoblastoma.
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