Spindle Fibers

Spindle fibers extend from the cell poles to align chromosomes at the metaphase plate.
During anaphase:
Spindle fibers pull the chromatids toward the spindle poles, and lengthen and elongate the cell.
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Spindle fibers
A collection of microtubules attached to a centromere during mitosis and meiosis that are responsible for the movement of the chromosomes to opposite poles.
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Spindle fibers have three destinations:
Some attach to one kinetochore of a dyad with those growing from the opposite centrosome binding to the other kinetochore of that dyad.
Some bind to the arms of the chromosomes.
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spindle fibers The protein fibers formed during prophase of nuclear division; chromosomes attach to these fibers at the centromere.
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The spindle fibers attach to the chromosomes and begin to move them to the center of the cell as they do in mitosis.
Metaphase I
Bivalents (tetrads) become aligned in the center of the cell and are attached to spindle fibers.
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The central portion of the chromosome to which the spindle fibers attach during mitotic and meiotic division. Chemotherapy. A treatment for cancers that involves ad- ministering chemicals toxic to malignant cells. Chloramphenicol.
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These spindle fibers become visible. The centrioles separate starting to radiate bundles of fibers, called asters. The spindle fibers run from one centriole to the other, at both poles of the cell.
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Some of the spindle fibers reach the chromosomes and attach to protein structures at the centromeres, called kinetochores, while others make contact with microtubules coming from the opposite pole.
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the pair of chromosomes that are attached to spindle fibers are aligned at the metaphase plate
Anaphase
the sister chromatids separates and chromosomes pull apart
identical copies are pulled part to each side of the cell by the spindle fibers ...
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Centromere: A specialized constricted region of a chromosome to which spindle fibers attach during cell division at which two sister chromatids (the two exact copies of each chromosome that are formed after replication) are joined, ...
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Centromere. The central portion of the chromosome to which the spindle fibers attach during mitotic and meiotic division.
Chemotherapy. A treatment for cancers that involves ad- ministering chemicals toxic to malignant cells.
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The term introduced by Darlington (1936) for the specialized chromosome region which reacts to the spindle at nuclear division and to which spindle fibers attach during cell division. Appears as a distinct "waist" by microscopy.
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The chromosomal attachment point for the spindle fibers located within the centromeres.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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The centromere is a region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis.
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During mitosis, chromosome separation requires spindle fibers made of microtubules; spindle inhibitors stop the synthesis of microtubules. Because most adult cells don't divide often, they are less sensitive to these drugs than are cancer cells.
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kinetochore: a region of DNA that has remained undivided during prophase of mitosis; binds to the spindle fibers that eventually pull apart the sister chromatids.
kingdom: the largest and broadest category of the classification system.
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During Prophase II, nuclear envelopes (if they formed during Telophase I) dissolve, and spindle fibers reform. All else is as in Prophase of mitosis. Indeed Meiosis II is very similar to mitosis.
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Centromere A specialized chromosome region to which spindle fibers attach during cell division.
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the structure located at a specific site on the chromosome that holds the two chromatids together; it is the site of attachment for the spindle fibers during cell division; also called primary constriction or kinetochore ...
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Microtubules also form the spindle fibers for separating chromosomes during mitosis. When arranged in geometric patterns inside flagella and cilia, they are used for locomotion.
See adjacent image.
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Prophase - phase of mitosis in which the chromatin duplicates itself and thickens into chromosomes, the spindle fibers form, and the nuclear membrane disintegrates ...
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