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Somatic hypermutation


Somatic Hypermutation (SHM)
Class Switch Recombination (CSR)
T Cells
Alpha/beta (αβ) T cells
Gamma/delta (γδ) T cells ...
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Somatic hypermutation: A very high frequency of mutational events that occur in specific loci, such as the variable segments of expressed immunoglobulin genes.
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For example, the vertebrate immune system shows that the variable environment of antigens has provided selective pressure for the use of adaptable codons and low-fidelity polymerases during somatic hypermutation.
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