Oncogene

oncogene
one of a small number of normal genes in vertebrates that are highly conserved evolutionarily and can cause cancer when they are mutant or inappropriately expressed ...
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Oncogenes
An oncogene is a gene that
when mutated or
expressed at abnormally-high levels ...
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An oncogene is a modified gene that increases the malignancy of a tumor cell. Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer.
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Oncogenes are generally mutated forms of normal cellular genes (proto-oncogenes). A gene capable, when activated, of transforming a cell.
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Oncogene
Growth factors
Growth factors are usually secreted by a few special cells to induce cell proliferation in other cells.
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Dr. Lawrence Brody, of the National Human Genome Research Institute's Genetic and Molecular Biology Branch, defines oncogene.
related
terms:
cancer, gene, protein, tumor suppressor gene ...
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Oncogene
A gene, one or more forms of which is associated with cancer. Many oncogenes are involved, directly or indirectly, in controlling the rate of cell growth.
Related Terms: Gene ...
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oncogenes Genes that can activate cell division in cells that normally do not divide or do so only slowly. A gene that when over-expressed leads to cancer, but which normally functions in cell division.
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Oncogenes and Signal Transduction
In normal cells, proto-oncogenes code for the proteins that send a signal to the nucleus to stimulate cell division.
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oncogene
(on-koh-jeen) [Gk. onkos, tumor + genos, birth, race]
A gene found in viruses or as part of the normal genome that is involved in triggering cancerous characteristics.
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Oncogenes
Proto-oncogenes are normal genes that are somehow involved in this process of cell division. Their DNA may contain the code for growth factors or some chemical that needs to be activated in order to stimulate cell division.
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oncogene Any of a number of genes that are associated with neoplastic growth (cancer). The gene in its benign state, either inactivated or carrying on its normal role, is a proto-oncogene.
oncomiracidium A ciliated larva of a monogenetic trematode.
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ONCOGENE - One of a number of genes believed to be associated with the malignant transformation of cells; originally identified in certain oncogenic retroviruses (v-onc) but also present in cells (c-onc). See PROTO-ONCOGENE.
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Oncogenesis. The progression of cytological, genetic, and cellular changes that culminate in a malignant tumor.
Open pollination. Pollination by wind, insects, or other natural mechanisms.
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Oncogene: A gene in a tumor virus or in cancerous cells which, when transferred into other cells, can cause transformation (note that only certain cells are susceptible to transformation by any one oncogene).
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Anti-oncogene. See Recessive oncogene. Antisense RNA. A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (See RNA.) Asexual reproduction.
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-oma tumor oncogene A gene of cellular or viral origin that causes cells to exhibit rapid, uncontrolled proliferation. See also proto-oncogene.
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Our targeted mutagenesis laboratory has already generated null mutants for two genes which are evolutionarily conserved between mice and humans, the proto-oncogene Evi-1, and the cytokine tumor necrosis factor-beta (TNF-), ...
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: One of the first phenomena in the formation of malignancies. It is due to defects in DNA repair and cell cycle controls. This can happen by gain-of-function mutations in proto-oncogenes or loss-of-function mutations in
tumor
suppressor genes.
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Oncogenes -- genes involved in cell cycle control (growth factors, growth factor regulator genes, etc), a mutation can lead to tumor growth.
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