Mouse

A mouse which carries experimentally introduced DNA in its genome. Linear DNA is injected into a fertilized embryo at the pro-nuclear stage and may be incorporated into the genome. Injected embryos are implanted into a foster mother.
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The nude mouse gets its name because it has no hair. But far more interesting, it is also born without a thymus. These traits result when the mouse is homozygous for a recessive mutant gene designated nu.
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A mouse that develops from an embryo created by the experimental fusion of two separate embryos (blastulas) from matings of different parents.
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2. From a mouse blastocyte (a very young embryo consisting of a ball of undifferentiated cells), stem cells are isolated; these can be grown in vitro. For this example, we will take a blastocyte from a white mouse.
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A laboratory mouse useful for medical research because it has specific characteristics that resemble a human disease or disorder. Strains of mice having natural mutations similar to human ones may serve as models of such conditions.
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Thus, a crippling heritable muscle disorder in mice maps to a location on the mouse X chromosome that is closely analogous to the map location for the X-linked human Duchenne muscular dystrophy gene (DMD).
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Chapter 18
Transgenic mouse models of Alzheimer's disease:phenotype and mechanisms of pathogenesis
Karen Duff
Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, U.S.A.
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Mouse embryonic stem cells. More lab photos
Stem cells are primal undifferentiated cells that retain the ability to divide and differentiate into other cell types. In higher plants this function is the defining property of the meristematic cells.
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The mouse, where one can make and characterize knockout mutants, is an excellent model system for studying genetic diseases of humans; its genome is remarkably similar to a human's.
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Source: Mouse Genome Informatics Glossary
DNA sequence
The relative order of base pairs, whether in a fragment of DNA, a gene, a chromosome, or an entire genome. See base sequence.
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Transgenic mouse: A mouse which carries experimentally introduced DNA. The procedure by which one makes a transgenic mouse involves the injection of DNA into a fertilized embryo at the pro-nuclear stage.
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A weed called mouse-eared cress has been designed to produce a biodegradable plastic called polyhydroxubutrate (PHB).
Possibilities for the Future ...
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He further noted that if heat killed S strain was injected into a mouse, it did not cause pneumonia.
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When tissue is transplanted from one strain (A) of mouse to a genetically related strain (B), the tissue survives.
However, when the tissue is transplanted to a different strain (C), the tissue is rejected.
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During the Cold War, the United States of America and the Soviet Union maintained large submarine fleets that engaged in cat-and-mouse games; Russia continues this tradition today.
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TRANSGENIC - An animal (usually a mouse) or plant into which a foreign gene has been introduced in the germ line. An example: transgenic mice expressing the human receptor for poliovirus are susceptible to human polioviruses.
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Rapid speciation of the Faeroe Island house mouse, which occurred in less than 250 years after man brought the creature to the island.
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: The major histocompatibility complex (
MHC
) of the mouse. It is the first MHC discovered in 1937 by Peter Gorer.
Hairpin loop ...
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Model organisms for developmental biology include the round worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, the zebrafish Brachydanio rerio, the mouse Mus musculus, and the weed Arabidopsis thaliana.
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