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Monoclonal Antibody


Monoclonal antibody
Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell.
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monoclonal antibody
(mon-oh-klone-ul)
A defensive protein produced by cells descended from a single cell; an antibody that is secreted by a clone of cells and, consequently, is specific for a single antigenic determinant.
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Monoclonal Antibody: An antibody with very specific and often unique binding specificity which is secreted by a biologically cloned line of plasmacytoma cells in the absence of other related antibodies with different binding specificities.
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a monoclonal antibody that binds CD33, a cell-surface molecule expressed by the cancerous cells in acute myelogenous leukemia (AML) but not found on the normal stem cells needed to repopulate the bone marrow.
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"Designed" monoclonal antibody therapy is already being employed in a number of diseases (including rheumatoid arthritis) and in some forms of cancer.
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One is what's known as a monoclonal antibody, or are sometimes known as antiglobin fusion proteins.
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In a model system, we have applied an example of the second method to the analysis of a monoclonal antibody epitope found in tissue transglutaminase (tTG).
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To demonstrate the molecular basis of the specificity of anti-neoepitope antibodies, the Fv region of a monoclonal antibody specific for a neoepitope generated by the ADAMTS-4-mediated cleavage of aggrecan has been modelled and the binding of the ...
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