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Monoclonal antibodies


Monoclonal Antibodies
Humans (and mice) have the ability to make antibodies able to
recognize (by binding to) virtually any antigenic determinant (epitope)
to discriminate between even similar epitopes.
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Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell.
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Monoclonal antibodies. Immunoglobulin molecules of single- epitope specificity that are secreted by a clone of B cells.
Monoculture. The agricultural practice of cultivating crops consisting of genetically similar organisms.
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Monoclonal antibodies took about 20 years from the time they first came on the scene to actually deliver us really wonderful, useful products- such as for treating autoimmune disease.
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(See monoclonal antibodies, polyclonal antibodies.) Anticodon. A nucleotide base triplet in a transfer RNA molecule that pairs with a complementary base triplet, or codon, in a messenger RNA molecule. See Codon, Messenger RNA, RNA. Antigen.
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Small molecules (such as the tyrosine kinase inhibitors imatinib and gefitinib) and monoclonal antibodies have proven to be a major step in oncological treatment.
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Memorial Sloan-Kettering Cancer Center, New York
Pioneering work in the use of "monoclonal antibodies" to treat cancer. Novel ways to produce a variety of radionuclides to treat lymphoma, leukemia, and prostate cancer.
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A cell resulting from the fusion of a spleen cell and myeloma cell. These cells can be cloned and maintained indefinitely in cell culture and produce monoclonal antibodies.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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Antibody: An immunoglobulin protein produced by B-lymphocytes of the immune system that binds to a specific antigen molecule. (See monoclonal antibodies, polyclonal antibodies.) ...
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monoclonal antibodies Antibodies produced by a cloned hybridoma cell, which therefore are identical and directed against the same epitope of an antigen. monolayer A single layer of oriented lipid molecules or cells.
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More sophisticated techniques are now in development that can track protein products without mitigating their function, such as the addition of small sequences which will serve as binding motifs to monoclonal antibodies.
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