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Lac repressor


The lac repressor (LacI) operates by binding to the operator region of the lac operon. This blocks RNA polymerase from binding, and so prevents transcription of the mRNA coding for the lac proteins.
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Lac repressor
The lac repressor is an enzyme which stops the metabolism of lactose in bacteria as long as glucose is available.
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The lac repressor binds to a specific sequence of two dozen nucleotides called the operator. [Link to a discussion of how the DNA sequence of the operator site can be determined.] Most of the operator is downstream of the promoter.
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Esipova N.G., Ebralidse K., and Mirzabekov, A.D. Mechanism of lac repressor switchoff: Orientation of lac repressor DNA-binding domain is reversed upon inducer binding. FEBS Lett. 1995. V.375. P.27-30 ...
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