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Intein


Some intein polypeptides are site-specific endonucleases as well as protein splicing catalysts. Endonuclease action results in insertion of the intein nucleic acid in a target site.
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Intein
Selfish DNA elements located within coding regions that are translated with the interrupted protein, but then catalyze their own excision and the formation of a peptide bond between the flanking protein regions.
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Inteins
Another, very rare, post-translational modification is the later removal of a section of the polypeptide and the splicing together (with a peptide bond) of the remaining N-terminal and C-terminal segments.
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The Intein Database Web site contains a registry of all submitted experimental and theoretical inteins (inframe protein introns) as well as information on protein splicing and intein structure.
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selfish DNA
noncoding DNA
intein
Reference
Walter Gilbert (1978 Feb 9) "Why Genes In Pieces?" Nature 271 (5645):501.
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Intramolecular transesterification, resulting in a branched polypeptide. In inteins, the new ester bond is broken by an intramolecular attack by the soon-to-be C-terminal asparagine.
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