Gene conversion

In asci of Ascomycete fungi a 4:4 ratio of alleles is expected after meiosis, yet 6:2 and 5:3 ratios are sometimes observed. A model of recombination, produced by Holliday, suggests that gene conversion may be explained by repair of heteroduplex DNA.
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Gene conversion
An genetic event that produces abnormal segregations by non-reciprocal recombination.
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Gene conversion shows polarity within a gene.
The observations are consistent with preferential initiation of recombination events at a hotspot, coupled with different extents of heteroduplex formation.
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Gene conversion during meiosis alters the normal mendelian ratios. Normally, meiosis in a heterozygous (A,a) parent will produce gametes or spores in a 1:1 ratio; e.g., 50% A; 50% a. However, if gene conversion has occurred, other ratios will appear.
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GENE CONVERSION - The alteration of all or part of a gene by a homologous donor DNA that is itself not altered in the process.
GENOME - The complete set of genetic information defining a particular animal, plant, organism or virus.
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Gene Conversion: The alteration of all or part of a gene by a homologous donor DNA that is itself not altered in the process.
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Gene conversion
: Partial sequence transfer from one allele to another (interallelic recombination) converting one gene or allele to another one. It is the most common mechanism, especially for the HLA-B locus, in the generation of new
MHC
alleles.
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One is gene conversion. This is a phenomena by which one stretch of DNA "erases" another stretch and copies itself in it's place. The mechanism is well known, but I don't have time to explain it. Any molecular bio text will have that info.
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Rozen, S., H. Skaletsky, J. D. Marszalek, P. J. Minx, H. S. Cordum, R. H. Waterson, R. K. Wilson, and D. C. Page. 2003. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. Nature 423:873-76.
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For humans and some other primates, the Y chromosome is able to "recombine" with itself (see below). This process, called gene conversion, may slow down the process of degradation.
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97 percent identical. The extensive use of gene conversion appears to play a role in the ability of the Y chromosome to edit out genetic mistakes and maintain the integrity of the relatively few genes it carries.
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The term was re-introduced by Lindegren (1953) to account for aberrant ratios in the products of meiosis, apparently arising from such interaction. Whitehouse and Hastings (1965) have suggested that if gene conversion is due to the correction of ...
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