Fusion Protein

Fusion Protein: A product of recombinant DNA in which the foreign gene product is juxtaposed ("fused") to either the carboxyl-terminal or amino-terminal portion of a polypeptide encoded by the vector itself.
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AKA: fusion protein
A protein derived from the Sendai virus which can be used in the laboratory to cause cell fusion between somatic cells (any cell that is not a gamete). It is also used to make fusogenic vesicles ...
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ABL and the fusion protein BCR-ABL are tyrosine kinases; that is, enzymes that attach phosphate groups to other proteins often activating them. Link to a discussion.
This unrestrained activation ...
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11-22 3 MOZ fusion proteins in acute myeloid leukaemia Philip J.F. Troke, Karin B. Kindle, Hilary M. Collins and David M. Heery..........23-39 4 Mechanistic studies of the mRNA transcription cycle Patrick Cramer..........
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For example if an organism is immunised against a GST-fusion protein it will produce antibodies against the fusion-protein, and possibly antibodies against the GST tag as well.
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Some expression vectors produce fusion proteins.
Filling-in In vitro synthesis of DNA (by DNA polymerase) to convert an overhanging end of a double-stranded DNA fragment to a blunt end.
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The identified clone produced a fusion protein with strong affinity for HS3. Immunofluorescence with antibodies against this fusion protein demonstrated a characteristic intranuclear pattern in HeLa cells and on the isolated nuclear matrix.
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Tamm is a professor of Biophysics at the University of Virginia where he is studying the structures and interactions of viral fusion proteins in lipid bilayers, mainly using the influenza surface protein, hemagglutinin (HA).
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^ Trends Biochem Sci. 1995 20(7):285-6 Purification of His-Tag fusion proteins from Escherichia coli
^ Nature. 2002 415(6868):141-7 Functional organization of the yeast proteome by systematic analysis of protein complexes ...
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fusion protein Depending on the context means one of two different things. Most commonly, refers to the protein product of a gene created by the fusion of two distinct genes, or portions of genes.
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