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Epitope


Chapter 9
Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
John S.Mort*1, Carl R. Flannery2, Joe Makkerh*3, Joanne C. Krupa* and Eunice R. Lee* ...
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Epitope
A portion of an antigen recognized by an antibody binding site. For protein antigens the epitope is typically 5-8 amino acids. Gene fusions to epitopes can be used as a tag to recognize specific proteins.
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epitope
A localized region on the surface of an antigen that is chemically recognized by antibodies; also called antigenic determinant.
equilibrium ...
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epitope Antigenic determinant; the portion of the antigen molecule displayed on the surface of an antigen-presenting cell (APC).
epizootic Massive infection rate among animals other than humans; identical to an epidemic in humans.
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Epitope: As related to protein antigens, B-cell epitopes consist of the amino acid residues of a protein molecule which interact directly through noncovalent bonds with the amino acid residues of a particular antibody molecule (complementarity ...
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Epitope
: The specific site on an antigen that is recognized by an antibody (also known as the antigenic determinant).
Escherichia coli ...
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Most epitopes are derived from polypeptides (proteins) and reflect the individuality of the pathogen.
Receptors are PRRs (pattern recognition receptors)
In jawed vertebrates, the receptors are B-cell (BCR) and T-cell (TCR) receptors for antigen ...
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Two very similar epitopes, Cc and Ee, appear to be closely related to Rh.
Rare phenotypes
Bombay phenotype ...
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Immunoglobulin molecules of single- epitope specificity that are secreted by a clone of B cells. Monoculture. The agricultural practice of cultivating crops consisting of genetically similar organisms. Monogenic.
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ePitope Informatics epitope prediction and analysis; protein epitopes
European Directory of DNA Laboratories (EDDNAL) intended mainly for clinical geneticists and molecular biologists.
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Each B-lymphocyte produces antibodies that are specific not to an antigen, but to an epitope of that antigen. An epitope is a small piece of the antigen to which the antibody binds.
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Monoclonal antibodies. Immunoglobulin molecules of single- epitope specificity that are secreted by a clone of B cells.
Monoculture. The agricultural practice of cultivating crops consisting of genetically similar organisms.
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A mixture of immunoglobulin molecules secreted against a specific antigen, each recognizing a different epitope.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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Different antibodies in the pool recognize different epitopes of the antigen. polylinker A short, usually synthetic, fragment of DNA containing recognition sequences for several restriction endonucleases employed to insert DNA into plasmids.
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So some of these amino acids would be located on the surface of the protein, directly accessible to the environment. Those amino acid residues would be the most that would constitute usually antigenic epitopes.
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