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DNA repair


DNA Repair
Importance
DNA in the living cell is subject to many chemical alterations (a fact often forgotten in the excitement of being able to do DNA sequencing on dried and/or frozen specimens [Link]).
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DNA Repair
Multiple systems for repairing damage to DNA have evolved, probably because of the importance of the DNA information content.
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DNA Repair Genes
A third type of gene associated with cancer is the group involved in DNA repair and maintenance of chromosome structure. Environmental factors, such asionizing radiation, UV light, and chemicals, can damage DNA.
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DNA repair genes Genes encoding proteins that correct errors in DNA sequencing.
DNA replication The use of existing DNA as a template for the synthesis of new DNA strands. In humans and other eukaryotes, replication occurs in the cell nucleus.
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DNA repair
: Restoration of the correct nucleotide sequence of a DNA molecule that has acquired a mutation or modification. It includes proofreading by
DNA polymerase
(see
helicase
).
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A DNA repair process initiated when DNA polymerase bypasses a damaged area. enzymes in the rec system are used.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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Post-replication repair
A DNA repair process which occurs after DNA replication.
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In 2005, scientists at Purdue University discovered in arabidopsis an alternative to previously known mechanisms of DNA repair, which one scientist called a "parallel path of inheritance". It was observed in mutations of the HOTHEAD gene.
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Because many of the DNA repair mechanisms of cells work only on paired bases, viruses that carry single-stranded DNA genomes mutate more frequently than they would otherwise. As a result, such species may adapt more rapidly to avoid extinction.
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Due to DNA replication and DNA repair mechanisms, mutation rates of individual genes are low, but since each organism has many genes, and a population has many individuals, new mutations arise in populations all the time.
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DNA ligase - protein that joins (ligates) DNA strands; used by cells for DNA repair, by molecular biologists for gene cloning.
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The closer together the markers are, the lower the probability that they will be separated during DNA repair or replication processes (binary fission in prokaryotes, mitosis or meiosis in eukaryotes), ...
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This process is the molecular basis of crossing over during meiosis and some DNA repair mechanisms. Another form of recombination, site-specific recombination, is found where transfer, rearrangement or insertion of specific sections of DNA occurs e.
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Lligase -- an enzyme that functions in DNA repair. Linkage -- the greater association in inheritance of two or more nonallelic genes than is to be expected from independent assortment; genes are linked because they reside on the same chromosome.
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