DNA damage

DNA damage, repair, and mutation. Mutations arise through damage to DNA that has not been repaired.
DNA rearrangements. Site-specific recombination and transposition mediated rearrangements require recognition of a specific target sequence.
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DNA damage checkpoints. These sense DNA damage
before the cell enters S phase (a G1 checkpoint);
during S phase, and
after DNA replication (a G2 checkpoint).
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John Battista (Louisiana State University): Enhance understanding of Deinococcus radiodurans and define the novel protein family responsible for DNA damage repair; ...
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SOS response In bacteria, a coordinated induction of a variety of genes as a response to high levels of DNA damage.
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The host cell, containing a dormant phage genome, experiences DNA damage due to a high stress environment, and starts to undergo the SOS response.
RecA (a cellular protein) detects DNA damage and becomes activated, RecA*, a highly specific protease.
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Response to stress or DNA damage
Stress conditions (such as starvation) as well as damage to the cell's DNA resulting from toxicity or exposure to ionizing radiation, such as ultraviolet or X-rays, can induce a cell to begin an apoptotic process.
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The coordinate induction of many genes in response to certain types of DNA damage.
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Other drugs cause extensive DNA damage, which stops replication. A class of drugs called spindle inhibitors stops cell replication early in mitosis.
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The error-prone process whereby gross structural DNA damage is circumvented by allowing replication to proceed past the damage through imprecise polymerization.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
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It can also be a cell's response to DNA damage and virus infection. Characteristics of apoptosis include activation of a Caspase pathway, digestion of structural proteins, degradation of chromosomal DNA, and phagocytosis of the cell.
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165-180 17 The p53 response during DNA damage: impact of transcriptional cofactors Amanda S. Coutts and Nicholas La Thangue..........181-189 18 The modulation of WTI transcription function by cofactors Stefan G.E. Roberts..........
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