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Pyrimidine



Pyrimidine
Chemical namePyrimidine
Chemical formulaC4H4N2
Molecular mass80.09 g/mol
Density1.016 g/ml
Melting point20 - 22 C
Boiling point123 - 124 C
CAS number289-95-2
SMILESC1=NC=NC=C1


Pyrimidine is a heterocyclic aromatic organic compound, which is similar to benzene and pyridine and that contains two nitrogen atoms at positions 1 and 3 of the six-membered ring.

Three nucleobases found in nucleic acids, namely cytosine, thymine, and uracil, are pyrimidine derivatives. In DNA and RNA, these bases form hydrogen bonds with their complementary purines.

purine  pyrimidine
   A         T
   G         C

In RNA, the complement of A is U instead of T:

purine  pyrimidine
   A         U
   G         C
Thymine Uracil Cytosine

These hydrogen bonding modes are for classical Watson-Crick base pairing. Other hydrogen bonding modes are available in both DNA and RNA, although the additional 2'-hydroxyl group of RNA expands the configurations through which RNA can form hydrogen bonds.

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